EVALUATION OF GASTROINTESTINAL FUNCTION USING PORTABLE ELECTROVISCEROGRAPHY SYSTEMS AND METHODS OF USING THE SAME

• US 20110040203A1
• Filed: 12/10/2009
• Published: 02/17/2011
• Est. Priority Date: 12/11/2008
• Status: Active Grant

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Colliou, Olivier, Strand, Angela, Savage, George, Hafezi, Hooman, Zdeblick, Mark
• Granted Patent: US 8,055,334 B2
• Time in Patent Office: Days
• US Class Current: 600/546
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/392 Detecting gastrointestinal contractions
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting

Abstract

Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.

Claims

1. A system for detection of myoelectric activity, the system comprising:

a receiver unit capable of detecting voltage potential changes, wherein the receiver unit comprises a transmission module for sending encoded information to a remote location and at least one sensor electrode to gather information from a proximal environment; and

an ingestible identifier in communication with the receiver unit, wherein the identifier comprises;

a housing including a first electrode and a second electrode secured thereto;

a control unit electrically coupled to the first and second electrodes, wherein the control unit changes the conductance between the first and second electrodes; and

a detection unit electrically coupled to the first and second electrodes, wherein the detection unit reads a surrounding environment to collect information,

wherein electrochemical reactions between the first electrode and the surrounding environment and the second electrode and the surrounding environment respectively produce a voltage potential that powers the ingestible identifier such that the control unit switches the ingestible identifier between broadcast mode and detection mode.

2. The system of claim 1, wherein the information encoded in the unique current signature produced by the ingestible identifier is identification information to indicate activation of the ingestible identifier to the receiver.

3. The system of claim 1, wherein the information encoded in the ingestible identifier'"'"'s unique current signature represents the data gathered during the detection stage.

4. The system of claim 1, wherein the receiver unit further comprises a second sensor electrode positioned apart from the at least one sensor electrode.

5. The system of claim 4, wherein the receiver further comprises a detection module capable of detecting low frequency current signals produced by a voltage potential and capable of detecting high frequency current signals produced by the ingestible identifier.

6. The system of claim 1, wherein the ingestible identifier further comprises a temperature sensing unit responsive to and capable of recording the surrounding temperature.

7. The system of claim 1, wherein the ingestible identifier includes a sensor capable of measuring the surrounding temperature.

8. The system of claim 1, wherein the ingestible identifier includes a sensor capable of measuring the surrounding pH level.

9. The system of claim 1 further comprising a second ingestible identifier wherein the second ingestible identifier communicates with the ingestible identifier such that when the second ingestible identifier is in broadcast mode, the ingestible identifier is in detection mode thereby allowing the ingestible identifiers to communicate.

10. The system of claim 9, further comprising a second receiver unit that includes at least three electrodes and wherein each of the electrodes of the second receiver unit transmits a control signal that is detected by each of the ingestible identifiers to create a detection array within the subject wherein the location of each ingestible identifier can be determined.

11. The system of claim 9, wherein the ingestible identifier measures acidic conditions and the second ingestible identifier measures alkaline conditions.

12. The system of claim 1, wherein the system further comprises an extra-corporeal data processor configured to receive data from the receiver unit and generate an electroviscerogram from the received data.

13. The system of claim 1, wherein the ingestible identifier includes a disc secured to the housing, wherein the disk is non-conducting and wherein during the detection mode the ingestible identifier records data associated with myoelectric activity and during the broadcast phase the ingestible identifier produces a unique current signature including the data.

14. The system of claim 1, wherein during the detection mode the ingestible identifier detects and records data associated an implantable device and during the broadcast phase the ingestible identifier produces a unique current signature encoded with the data.

15. A system for creating an electroviscerogram for a subject based on detected myoelectric activity, the system comprising:

a receiver unit capable of detecting voltage potential changes associated with a subject, wherein the receiver unit comprising;

a housing having at least two electrodes secured thereto for detection of a change in voltage potential associated with myoelectric activity of the subject;

a processing unit for receiving the detected myoelectric information and providing an encoded message; and

a transmission module secured to the housing and electrically coupled to the processing unit, wherein the transmission module receives the encoded message from the processing unit; and

a decoding system comprising;

a receiver module in communication with the transmission module, wherein the receiver module receives the transmitted encoded message and decodes the transmitted encoded message to produce a decoded message;

a display module for receiving the decoded message and producing the electroviscerogram.

16. The system of claim 15, further comprising an identifier unit in communication with the receiver unit, wherein the identifier unit comprises:

a housing including a first material and a second material secured to different surfaces of the housing, wherein the first and second material are selected to generate an electrochemical potential difference when in contact with a conducting fluid;

a non-conducting membrane positioned between the first and second material and secured to the housing; and

a control unit electrically coupled to the first and second materials, wherein the control unit changes the conductance path between the first and second materials to produce a unique current signature that can be detected by the receiver unit.

17. The system of claim 16, wherein the identifier unit further comprises a detection unit electrically coupled to the first and second materials, wherein the detection unit reads the surrounding environment to collect information.

18. The system of claim 17, wherein the control unit switches the identifier unit between broadcast mode and detection mode.

19. The system of claim 18, wherein the identifier unit operated in detection mode to gather information associated with an implanted pulse generator and wherein during broadcast mode the identifier unit produces a unique current signature containing the information associated with the implanted pulse generator.

20. The system of claim 18, wherein the information collected about the surrounding environment is myoelectric activity and wherein the identifier unit includes a sensor that detects a physiological parameter and combines the data associated with the physiological parameters with the data associated with myoelectric activity and during broadcast mode the identifier unit produces a unique current signature containing the combined information.