Particle Delivery
First Claim
1. A system for delivering particles to a patient;
- the system comprising;
an infusion device having a reservoir configured to house the particles;
a delivery element having a proximal end, a distal end, a delivery region between the proximal end and the distal end, and a lumen extending from the proximal end to the delivery region, the delivery element being operably couplable to the syringe such that particles from the reservoir of the syringe are deliverable via the delivery region of the delivery element;
a polymeric carrier slidably disposed in the lumen of the catheter, wherein delivery of the particles from the reservoir via the delivery region of the delivery element causes the polymeric carrier to exit to the delivery region of the delivery element.
2 Assignments
0 Petitions
Accused Products
Abstract
A method for delivering particles to a target location of a subject includes slidably disposing a polymeric carrier in a lumen of a catheter. The lumen extends in the catheter from a proximal opening to a delivery region. The method further includes inserting the delivery region of the catheter in the target location of the subject and forcing the particles through the lumen of the catheter to cause the carrier and the particles to exit the delivery region of the catheter. The particles may be cells or drug-loaded microspheres. The carrier can serve to retain the particles in the target location for a period of time. For treatment of vertebral disc degeneration, the particles can be stem cells, the carrier can be formed from collagen, and the target location can be the nucleus pulposus.
32 Citations
31 Claims
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1. A system for delivering particles to a patient;
- the system comprising;
an infusion device having a reservoir configured to house the particles; a delivery element having a proximal end, a distal end, a delivery region between the proximal end and the distal end, and a lumen extending from the proximal end to the delivery region, the delivery element being operably couplable to the syringe such that particles from the reservoir of the syringe are deliverable via the delivery region of the delivery element; a polymeric carrier slidably disposed in the lumen of the catheter, wherein delivery of the particles from the reservoir via the delivery region of the delivery element causes the polymeric carrier to exit to the delivery region of the delivery element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- the system comprising;
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13. A method comprising:
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slidably disposing a polymeric carrier in a lumen of a delivery element, the lumen extending in the delivery element from a proximal opening to a delivery region; forcing particles through the lumen of the delivery element to cause the carrier and the particles to exit the delivery region of the delivery element. - View Dependent Claims (14, 15, 16)
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17. A method for delivering cells to a subject, comprising:
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delivering cells from a reservoir through a delivery element to the subject; and delivering a polymeric carrier from the delivery element to the subject, wherein delivering the cells from the reservoir through the delivery element causes the polymeric carrier to be delivered from the delivery element to the subject. - View Dependent Claims (18, 19, 20, 21, 22)
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23. A method for treating disc degeneration in a subject in need thereof, comprising:
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delivering stem cells from a reservoir through a delivery element to a nucleus pulposus of the subject; and delivering a collagen carrier from the delivery element to the nucleus pulposus of the subject, wherein delivering the cells from the reservoir through the delivery element causes the collagen carrier to be delivered from the delivery element to the subject. - View Dependent Claims (24)
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25. A kit comprising:
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a delivery element having a fluid delivery lumen; and a polymeric carrier slidably disposed in the lumen such that, when fluid is delivered via the lumen, the polymeric carrier is expelled from the lumen. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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Specification