Organisms homozygous for targeted modification
First Claim
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1. An organism that is homozygous for a modification at a gene locus having at least first and second alleles, wherein(i) the first and second alleles of the gene locus comprise one or more deletions such that the gene locus is inactivated and further wherein the first and second alleles do not comprise exogenous sequences;
- or(ii) the first and second alleles of the gene locus comprise one or more exogenous sequences, wherein the one or more exogenous sequences do not encode a reporter or selectable marker.
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Abstract
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
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Citations
19 Claims
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1. An organism that is homozygous for a modification at a gene locus having at least first and second alleles, wherein
(i) the first and second alleles of the gene locus comprise one or more deletions such that the gene locus is inactivated and further wherein the first and second alleles do not comprise exogenous sequences; - or
(ii) the first and second alleles of the gene locus comprise one or more exogenous sequences, wherein the one or more exogenous sequences do not encode a reporter or selectable marker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification