Electrochemical Assays

• US 20110042241A1
• Filed: 12/22/2008
• Published: 02/24/2011
• Est. Priority Date: 12/24/2007
• Status: Abandoned Application

• Current Assignee: Oxtox Limited
• Original Assignee: Oxtox Limited
• Inventors: Kotsis, Angelo, Bonifer, Claudia, McMillan, Peter, Parselle, John, Brown, John
• Application Number:
  US12/810,366
• Publication Number:
  US 20110042241A1
• Time in Patent Office: Days
• US Class Current: 205/792
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00

Abstract

A fluid assay system comprises a swab having an absorbent portion for receiving and retaining a fluid sample. The system also comprises an electrode module having at least one electrode, arranged so that it can be selectively placed over the absorbent portion of the swab in order to contact the electrode with the fluid sample. The system further comprises a reader module configured to process signals from the electrode module, with the electrode and reading modules arranged such that they can be coupled together for communication of the signals from the electrode module to the reader module.

Claims

1-43. -43. (canceled)

44. A fluid assay system comprising a swab having an absorbent portion for receiving and retaining a fluid sample, an electrode module comprising at least one electrode, said module being arranged such that it can be selectively placed over said absorbent portion in order to contact said electrode with said fluid sample;

the system further comprising a reader module configured to process signals from said electrode module, wherein said electrode module and said reading module are arranged such that they can be coupled together for communication of said signals from said electrode module to said reader module.

45. A system as claimed in claim 44 wherein the electrode module is removable from the reader module.

46. A system as claimed in claim 44 wherein the electrode module and swab are designed for single use.

47. A system as claim in claim 44 wherein the electrode module can be locked in place over the absorbent portion of the swab member.

48. A system as claimed in claim 44 wherein the electrodes are adapted to detect one or more of:

phenols, phenolic compounds and phenol derivatives.

49. A system as claimed in claim 44 wherein the electrode module comprises a direct connection to the electrodes, and the reader module comprises means for processing or filtering of the signals from the electrodes.

50. A system as claimed in claim 49 wherein the coupling between the electrode module and the reader module comprises a plug-and-socket arrangement.

51. A system as claimed in claim 50 wherein the reader module is configured to identify or verify the electrode module.

52. A system as claimed in claim 50 wherein the reader module is configured to determine automatically what type of electrode module is connected to it, and to perform an appropriate analysis.

53. A system as claimed in claim 44 wherein the electrode module is, or is able to be, rotatably fitted to the swab so as to have an open configuration allowing access to the absorbent portion in order to collect a fluid sample;

and a closed configuration in which the absorbent portion is inside the electrode module so that the electrodes thereof can come into contact with the fluid sample.

54. A system as claimed in claim 44 wherein the electrode module can be slid over the absorbent portion of the swab member.

55. A system as claimed in claim 44 wherein the electrode module is permanently fitted to the swab.

56. A system as claimed in claim 44 wherein the electrode module can be fitted over the absorbent portion by a user.

57. A system as claimed in claim 44 wherein the electrode module comprises a working electrode, a counter electrode and a reference electrode.

58. A system as claimed in claim 44 wherein either or both of the electrode module and the swab is configured to apply a contact pressure between said electrodes and the fluid sample retained in the absorbent portion.

59. A system as claimed in claim 58 wherein either or both of the electrode module and the swab comprise resilient means to apply the contact pressure.

60. A system as claimed in claim 58 wherein the pressure is provided by the action of sliding, rotating or otherwise moving the electrode module over the absorbent portion.

61. A system as claimed in claim 58 comprising means for applying the pressure independently of the action of bringing the electrode module and absorbent portion into registration.

62. A system as claimed in claim 58 wherein the contact pressure is provided by the action of locking the electrode module to the swab.

63. A system as claimed in claim 62 wherein said locking action is coupled to the action of bringing the electrode module into registration with the absorbent portion of the swab.

64. A system as claimed in claim 44 wherein the swab comprises an elongate member with the absorbent portion at one end.

65. A system as claimed in claim 44 wherein the swab is sterile for collecting human saliva samples.

66. A system as claimed in claim 44 wherein the electrode module comprises a plurality of working electrodes.

67. A system as claimed in claim 66 wherein two or more working electrodes share a common reference or counter electrode.

68. A system as claimed in claim 66 wherein the plurality of working electrodes is arranged around a common reference or counter electrode.

69. A system as claimed in claim 66 wherein the electrode module comprises between 2 and 30 working electrodes, preferably between 5 and 20 working electrodes, more preferably between 8 and 16 working electrodes.

70. A system as claimed in claim 66 wherein the working electrodes are each less than 2 mm wide, preferably less than 1 mm wide.

71. A system as claimed in claim 66 wherein the plurality of working electrodes are connected together on the electrode module so as to act effectively as a single distributed electrode.

72. A system as claimed in claim 66 wherein the plurality of working electrodes have individual contacts to allow electrical connection to be made to them individually.

73. A system as claimed in claim 66 wherein the contacts for the electrodes are provided along one edge of the electrode module.

74. Use of a system as claimed in claim 44 for the electrochemical assaying of human saliva samples.

75. An electrode module for an electrochemical assay, comprising a plurality of working electrodes on a common substrate.

76. An electrode module as claimed in claim 75 comprising a plurality of working electrodes for a single given analyte.

77. An electrode module as claimed in claim 75 wherein the plurality of working electrodes are configured to detect two or more analytes.

78. An electrode module as claimed in claim 75 wherein the electrode module is adapted to detect any or all substances from the group comprising cannabis, amphetamines, cocaine, opiates and benzodiazepines.

79. An electrode module as claimed in claim 75 wherein two or more working electrodes share a common reference or counter electrode.

80. An electrode module as claimed in claim 75 wherein the plurality of working electrodes is arranged around a common reference or counter electrode.

81. An electrode module as claimed in claim 75 wherein the electrode module comprises between 2 and 30 working electrodes, preferably between 5 and 20 working electrodes, more preferably between 8 and 16 working electrodes.

82. An electrode module as claimed in claim 75 wherein the working electrodes are each less than 2 mm wide, preferably less than 1 mm wide.

83. An electrode module as claimed in claim 75 wherein the plurality of working electrodes are connected together on the electrode module so as to act effectively as a single distributed electrode.

84. An electrode module as claimed in claim 75 wherein the plurality of working electrodes have individual contacts to allow electrical connection to be made to them individually.

85. An electrode module as claimed in claim 75 wherein the contacts for the electrodes are provided along one edge of the electrode module.

86. Use of an electrode module as claimed in claim 75 for the electrochemical assaying of human saliva samples.

87. A reader module adapted to be used in association with the electrode module as claimed in claim 75.

88. A reader module as claimed in claim 87 wherein the reader module is configured to address the working electrodes in parallel.

89. Use of a reader module as claimed in claim 87 for the electrochemical assaying of human saliva samples.

90. An electrochemical assay system comprising a plurality of electrodes adapted to detect a plurality of analytes in a single fluid sample.

91. A system as claimed in claim 90 comprising a disposable electrode module.

92. Use of a system as claimed in claim 90 for the electrochemical assaying of human saliva samples.