OPTICAL READER SYSTEM AND METHOD FOR MONITORING AND CORRECTING LATERAL AND ANGULAR MISALIGNMENTS OF LABEL INDEPENDENT BIOSENSORS
First Claim
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1. A method for detecting and correcting a misalignment of a microplate in an optical reader system, said method comprising the steps of:
- placing said microplate onto a holder;
using a fiducial marking on said microplate to determine a first position of said microplate;
removing said microplate from said holder;
re-inserting said microplate back onto said holder;
using said fiducial marking on said microplate to determine a second position of said microplate;
comparing the first position and the second position of said microplate; and
if there is a difference between the two positions, then addressing the lateral and/or angular misalignment of said microplate such that the re-inserted microplate is positioned to be located at or substantially near to the first position, wherein said fiducial marking on said microplate is a coating.
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Abstract
An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.
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Citations
18 Claims
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1. A method for detecting and correcting a misalignment of a microplate in an optical reader system, said method comprising the steps of:
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placing said microplate onto a holder; using a fiducial marking on said microplate to determine a first position of said microplate; removing said microplate from said holder; re-inserting said microplate back onto said holder; using said fiducial marking on said microplate to determine a second position of said microplate; comparing the first position and the second position of said microplate; and if there is a difference between the two positions, then addressing the lateral and/or angular misalignment of said microplate such that the re-inserted microplate is positioned to be located at or substantially near to the first position, wherein said fiducial marking on said microplate is a coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An optical reader system comprising:
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a holder for supporting a biosensor; a light source for creating an optical beam which is scanned across a fiducial marking associated with the biosensor; a detector for collecting the scanned optical beam which is reflected from the fiducial marking associated with the biosensor; a processor for analyzing the collected optical beam and determining a position of the biosensor; and said processor for addressing a lateral and/or an angular misalignment of the biosensor, if needed. - View Dependent Claims (13, 14, 15)
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16. A microplate comprising:
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a frame including a plurality of wells formed therein, each well incorporating a biosensor that includes; a substrate; a measurement diffraction grating; and a waveguide film; and said frame further includes at least one fiducial marking located thereon which is used to help determine a position of the biosensors. - View Dependent Claims (17, 18)
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Specification