Stabilized Angiopoietin-2 Antibodies And Uses Thereof
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0 Petitions
Accused Products
Abstract
Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.
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Citations
104 Claims
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1-85. -85. (canceled)
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86. An isolated antibody that binds to angiopoietin-2 (Ang-2), wherein the antibody comprises a light chain variable region of;
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a) SEQ ID No;
3 (MEDI1);b) SEQ ID No;
4 (MEDI2);c) SEQ ID No;
5 (MEDI3);d) SEQ ID No;
6 (MEDI4);
ore) SEQ ID No;
8 (MEDI6). - View Dependent Claims (87, 88, 89, 90, 91, 92)
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93. An isolated nucleic acid encoding at least one isolated antibody that binds to Ang-2 comprising a heavy and light chain variable region of SEQ ID No:
- 3 (MEDI1) and SEQ ID No;
7 (MEDI5).
- 3 (MEDI1) and SEQ ID No;
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94. A pharmaceutical composition comprising:
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a) an isolated antibody that binds to Ang-2, wherein the antibody comprises a light chain variable region of SEQ ID No;
3 (MEDI1) and a heavy chain variable region of SEQ ID No;
7 (MEDI5); and
,b) an excipient.
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95. A method of inhibiting angiogenesis of a cancer tumor in an animal in need thereof, wherein the method comprises administering to the animal a composition comprising;
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a) an isolated antibody that binds to Ang-2, wherein the antibody comprises a light chain variable region of SEQ ID No;
3 (MEDI1) and a heavy chain variable region of SEQ ID No;
7 (MEDI5); and
,b) an excipient. - View Dependent Claims (96, 97, 98)
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99. A method of preventing, treating, or managing disease-related angiogenesis in an animal in need thereof, wherein the method comprises administering a composition comprising;
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a) an isolated antibody that binds to Ang-2; and
,b) an excipient. - View Dependent Claims (100, 101, 102, 103, 104)
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Specification