HEMOSTATIC IMPLANT

• US 20110045047A1
• Filed: 11/03/2010
• Published: 02/24/2011
• Est. Priority Date: 10/17/2008
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Confluent Surgical, Inc. (Medtronic Plc), Tyco Healthcare Group LP (Medtronic Plc)
• Inventors: Sargeant, Timothy, Bennett, Steven
• Granted Patent: US 9,889,230 B2
• Time in Patent Office: Days
• US Class Current: 424/422
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

The present disclosure relates to collagen-containing implants including a porous substrate having a first hydrogel precursor and a second hydrogel precursor applied thereto in a manner such that the first hydrogel precursor and second hydrogel precursor do not react with each other until the implant is placed at the site of implantation and exposed to the physiological fluids of a patient.

Claims

1. An implant comprising:

a porous substrate having a first hydrogel precursor comprising collagen applied to the porous substrate; and

a film containing a second hydrogel precursor applied to the porous substrate.

2. The implant of claim 1, wherein the porous substrate is a foam.

3. The implant of claim 1, wherein the porous substrate is a knitted textile.

4. The implant of claim 1, wherein the porous substrate is a non-woven textile.

5. The implant of claim 1, wherein the porous substrate is made from a bioabsorbable material.

6. The implant of claim 1, wherein the porous substrate is made from a non-bioabsorbable material.

7. The implant of claim 1, wherein the porous substrate is made from oxidized cellulose.

8. The implant of claim 1, wherein the first hydrogel precursor comprises particles.

9. The implant of claim 1, wherein the first hydrogel precursor further comprises at least one basic salt comprising borates, carbonates, phosphates, bicarbonates, and combinations thereof.

10. The implant of claim 1, further comprising a bioactive agent.

11. An implant comprising:

a porous substrate having a first hydrogel precursor comprising collagen applied to a first portion of the porous substrate; and

a second hydrogel precursor applied to a second portion of the porous substrate,

wherein the first portion of the substrate is spatially separated from the second portion of the porous substrate.

12. The implant of claim 11, wherein the porous substrate is a foam.

13. The implant of claim 11, wherein the porous substrate is a knitted textile.

14. The implant of claim 11, wherein the porous substrate is a non-woven textile.

15. The implant of claim 11, wherein the porous substrate is made from a bioabsorbable material.

16. The implant of claim 11, wherein the porous substrate is made from a non-bioabsorbable material.

17. The implant of claim 11, wherein the porous substrate is made from oxidized cellulose.

18. The implant of claim 11, wherein the first hydrogel precursor comprises particles.

19. The implant of claim 11, wherein the second hydrogel precursor is a foam.

20. The implant of claim 11, wherein the second hydrogel precursor is a film.

21. The implant of claim 11, further comprising a bioactive agent.

22. The implant of claim 11, wherein the first hydrogel precursor further comprises at least one basic salt comprising borates, carbonates, phosphates, bicarbonates, and combinations thereof.

23. A method comprising:

identifying a defect in cartilage;

orienting a porous substrate having a first hydrogel precursor comprising collagen applied to a first portion of the porous substrate and a second hydrogel precursor applied to a second portion of the porous substrate, with the second portion nearer to a patient'"'"'s tissue within the defect than the first portion; and

contacting the oriented implant with the patient'"'"'s tissue,

wherein physiological fluids wet the second portion and are wicked through the porous substrate so that the first hydrogel precursor reacts with the second hydrogel precursor, thereby forming a hydrogel.

24. The method as in claim 23, wherein the first hydrogel precursor comprises particles.

25. The method as in claim 23, wherein the second hydrogel precursor is applied to the porous substrate as a film.

26. The method as in claim 23, wherein the first portion of the substrate is spatially separated from the second portion of the porous substrate.

27. The method as in claim 23, wherein the first hydrogel precursor further comprises at least one basic salt comprising borates, carbonates, phosphates, bicarbonates, and combinations thereof.