TISSUE COATING FOR PREVENTING UNDESIRED TISSUE-TO-TISSUE ADHESIONS
First Claim
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1. A kit suitable for forming a tissue coating that is capable of preventing undesired tissue-to-tissue adhesions comprising:
- a) at least one carboxymethyldextran that has been derivatized to provide at least one aminocarboxymethyldextran that contains primary amine groups, said at least one carboxymethyldextran having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, and a degree of carboxymethylation of about 0.1 to about 2.5, said at least one aminocarboxymethyldextran having a primary amine substitution level of about 10% to about 150%; and
b) at least one carboxymethylcellulose that has been oxidized to provide at least one oxidized carboxymethylcellulose containing aldehyde groups, said at least one oxidized carboxymethylcellulose having a weight-average molecular weight of about 5,000 to about 100,000 Daltons, and an equivalent weight per aldehyde group of about 125 to about 750 Daltons.
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Abstract
Disclosed herein are a kit and a method for forming a tissue coating that prevents undesired tissue-to-tissue adhesions resulting from trauma, surgery, infection, or other stimulus. The tissue coating is a hydrogel formed by reacting an aminocarboxymethyldextran containing primary amine groups with an oxidized carboxymethylcellulose containing aldehyde groups.
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Citations
15 Claims
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1. A kit suitable for forming a tissue coating that is capable of preventing undesired tissue-to-tissue adhesions comprising:
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a) at least one carboxymethyldextran that has been derivatized to provide at least one aminocarboxymethyldextran that contains primary amine groups, said at least one carboxymethyldextran having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, and a degree of carboxymethylation of about 0.1 to about 2.5, said at least one aminocarboxymethyldextran having a primary amine substitution level of about 10% to about 150%; and b) at least one carboxymethylcellulose that has been oxidized to provide at least one oxidized carboxymethylcellulose containing aldehyde groups, said at least one oxidized carboxymethylcellulose having a weight-average molecular weight of about 5,000 to about 100,000 Daltons, and an equivalent weight per aldehyde group of about 125 to about 750 Daltons. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A dried hydrogel formed by a process comprising the steps of:
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a) reacting in a solvent (i) at least one carboxymethyldextran that has been derivatized to provide at least one aminocarboxymethyldextran that contains primary amine groups, said at least one carboxymethyldextran having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, and a degree of carboxymethylation of about 0.1 to about 2.5, said at least one aminocarboxymethyldextran having a primary amine substitution level of about 10% to about 150%;
with (ii) at least one carboxymethylcellulose that has been oxidized to provide at least one oxidized carboxymethylcellulose containing aldehyde groups, said at least one oxidized carboxymethylcellulose having a weight-average molecular weight of about 5,000 to about 100,000 Daltons, and an equivalent weight per aldehyde group of about 125 to about 750 Daltons, to form a hydrogel; andb) treating said hydrogel to remove at least a portion of said solvent to form the dried hydrogel. - View Dependent Claims (13, 14)
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15. A method for forming a tissue coating that is capable of preventing undesired tissue-to-tissue adhesions comprising:
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applying to an anatomical site on tissue of a living organism; a) at least one carboxymethyldextran that has been derivatized to provide at least one aminocarboxymethyldextran that contains primary amine groups, said at least one carboxymethyldextran having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, and a degree of carboxymethylation of about 0.1 to about 2.5, said at least one aminocarboxymethyldextran having a primary amine substitution level of about 10% to about 150%;
followed byb) at least one carboxymethylcellulose that has been oxidized to provide at least one oxidized carboxymethylcellulose containing aldehyde groups, said at least one oxidized carboxymethylcellulose having a weight-average molecular weight of about 5,000 to about 100,000 Daltons, and an equivalent weight per aldehyde group of about 125 to about 750 Daltons; or applying (b) followed by (a) and mixing (a) and (b) on the site;
orpremixing (a) and (b) and applying the resulting mixture to the site.
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Specification