On-Site Liquid Production

• US 20110045498A1
• Filed: 08/25/2008
• Published: 02/24/2011
• Est. Priority Date: 08/29/2007
• Status: Abandoned Application

• Current Assignee: Dako Denmark A/S (Agilent Technologies, Inc.)
• Original Assignee: Dako Denmark A/S (Agilent Technologies, Inc.)
• Inventors: Lindberg, Martin, Winther, Lars
• Application Number:
  US12/675,232
• Publication Number:
  US 20110045498A1
• Time in Patent Office: Days
• US Class Current: 435/7.21
• CPC Class Codes: G01N 2035/00138 Slides
• CPC Class Codes: G01N 2035/00217 involving measurement of weight
• CPC Class Codes: G01N 2035/00544 using fluid flow
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence

Abstract

A biological sample processing system for on-site liquid production comprises a processing apparatus for processing of biological samples arranged on microscope slides, and a production unit connected to the apparatus. The production unit comprises a first ingredient source, a second ingredient source, and a mixer station. The mixer station is configured to mix ingredients to produce a liquid product. Supply conduits are arranged to supply an amount of a first ingredient and an amount of a second ingredient from the first and second ingredient sources to the mixer station. A delivery conduit is provided for transportation of an amount of the liquid product from the mixer station. A production controller is arranged in communication with the production unit, and is configured to control the operation of the production unit.

Claims

1. A biological sample processing system, comprising:

a biological sample processing apparatus for processing of biological samples arranged on microscope slides;

a production unit connected to the biological sample processing apparatus, the production unit comprising;

a first ingredient source of a first ingredient;

a second ingredient source of a second ingredient;

a mixer station comprising a mixing chamber having a mixer inlet and a mixer outlet, the mixer station being configured to mix ingredients in the mixing chamber to produce a liquid product;

a first supply conduit for supply of an amount of the first ingredient from the first ingredient source to the mixing chamber via the mixer inlet;

a second supply conduit for supply of an amount of the second ingredient from the second ingredient source to the mixing chamber via the mixer inlet;

a delivery conduit for transportation of an amount of the liquid product from the mixing chamber via the mixer outlet; and

a production controller arranged in communication with the production unit, the production controller comprising;

a processor; and

a memory device in communication with the processor, the memory device comprising a computer program which the processor is configured to access to control the operation of the production unit.

2. The biological sample processing system of claim 1, further comprising a sample processing apparatus controller SC arranged in communication with the sample processing apparatus, and being configured to:

control and monitor various processes, functions, or components, that are implemented on or relate to the operation of the sample processing apparatus; and

to

schedule the production of liquids in the production unit.

3. The biological sample processing system of claim 2, further comprising a system manager server SMS arranged in communication with the production controller and the sample processing apparatus controller SC, and configured to control the production controller, and wherein the sample processing apparatus controller SC is configured to transfer data to and from the system manager server SMS.

4. The biological sample processing system of claim 3, further comprising a system manager SM arranged in communication with the system manager server SMS and configured to provide a user to connect to, and to transfer data to and from the system manager server SMS.

5. The biological sample processing system of claim 1, further comprising a water tap, water conduit, a water supply regulator for supplying an amount of water to the first ingredient source or to the mixer station, and a purifier arranged to purify the water transported in water conduit, wherein the purifier is a filtration device or a separator configured to use reverse osmosis to purify the water.

6. The biological sample processing system of claim 1, further comprising at least one quality control station arranged to control the quality of liquid supplied to, supplied within or supplied from the production unit.

7. The biological sample processing system of claim 1, further comprising:

a first supply flow regulator arranged at the first supply conduit, arranged to be controlled by the production controller and arranged to supply an amount of the first ingredient to the mixing chamber in response to control instructions from the production controller;

a second supply flow regulator arranged at the second supply conduit, arranged to be controlled by the production controller and arranged to supply an amount of the second ingredient to the mixing chamber in response to control instructions from the production controller; and

a delivery flow regulator arranged at the delivery conduit, arranged to be controlled by the production controller and arranged to transport an amount of the liquid product from the mixing chamber in response to control instructions from the production controller.

8. The biological sample processing system of claim 7, wherein the delivery flow regulator is configured to transport an amount of the liquid product to a second or third quality control station arranged to control the quality of the liquid product, and configured to transport quality controlled liquid product to a production unit outlet or to a liquid storage station for storage.

9. The biological sample processing system of claim 8, further comprising an antimicrobial device arranged in the liquid storage station and configured to prevent bacterial growth in the liquid storage station, and wherein the antimicrobial device comprises a heat source or a UV source.

10. The biological sample processing system of claim 8, further comprising one or more fluid containers comprised on one or more fluidics carts, the one or more fluid containers being in fluid communication with the production unit outlet, whereby liquid product can be supplied from the production unit to one or more of the fluid containers, and wherein the fluidics cart is arranged in communication with the sample processing apparatus controller SC that is configured to control the supply of fluid from the fluid container on the fluidics cart to the sample processing apparatus.

11. The biological sample processing system of claim 1, further comprising determination means for determining the amount of ingredient comprised in the mixing chamber, the determination means being arranged at the mixer station and arranged in communication with the production controller, and being configured to communicate the amount of ingredient to the production controller, whereby the production controller can determine if more ingredient is to be supplied or if sufficient ingredient has been supplied and whereby the production unit controller can control the production unit accordingly.

12. The biological sample processing system of claim 1, wherein at least one of the first and second ingredient sources is configured as a flexible bag comprising the first or second ingredient, and wherein the flexible bag is comprised in a box in a so-called bag-in-a-box configuration.

13. The biological sample processing system of claim 1, wherein the liquid product is produced as a batch or is produced continuously, and/or wherein the liquid product is produced on demand.

14. The biological sample processing system of claim 1, wherein the first ingredient is purified water, the second ingredient is a buffer concentrate and the liquid product is a buffer solution.

15. The biological sample processing system of claim 1, wherein the production controller is configured to control the production unit to produce the liquid product in dependence on the consumption of the liquid product by the sample processing apparatus.

16. A method for liquid production in a biological sample processing system, comprising the steps of:

providing a biological sample processing apparatus for processing of biological samples arranged on microscope slides;

providing a production unit connected to the biological sample processing apparatus, the production unit comprising;

a first ingredient source of a first ingredient;

a second ingredient source of a second ingredient;

a mixer station comprising a mixing chamber having a mixer inlet and a mixer outlet, the mixer station being configured to mix ingredients in the mixing chamber to produce a liquid product;

providing a production controller arranged in communication with the production unit, the production controller comprising;

a processor; and

a memory device in communication with the processor, the memory device comprising a computer program which the processor is configured to access to control the operation of the production unit;

supplying an amount of the first ingredient from the first ingredient source to the mixing chamber in dependence of control instructions from the production controller;

supplying an amount of the second ingredient from the second ingredient source to the mixing chamber in dependence of control instructions from the production controller;

mixing in the mixer chamber the amount of the first ingredient and the amount second ingredient in dependence of control instructions from the production controller to produce the liquid product; and

transporting an amount of the liquid product from the mixing chamber via the mixer outlet.

17. The method of claim 16, further comprising the steps of:

providing a sample processing apparatus controller SC in communication with the sample processing apparatus;

controlling and monitoring various processes, functions, or components, that are implemented on or relates to the operation of the sample processing apparatus by means of the sample processing apparatus controller SC; and

scheduling the production of liquids in the production unit by means of the sample processing apparatus controller SC.

18. The method of claim 17, further comprising the steps of:

providing a system manager server SMS arranged in communication with the production controller and the sample processing apparatus controller SC; and

controlling the production controller by means of the system manager server SMS.

19. The method of claim 18, further comprising the steps of:

providing a system manager SM arranged in communication with the system manager server SMS;

providing a user to connect to, and to transfer data to and from the system manager server SMS by means of the a system manager SM.

20. The method of claim 19, further comprising the step of providing at least one quality control station arranged to control the quality of liquid supplied to, supplied within or supplied from the production unit.

21. The method of claim 16, further comprising the steps of:

providing a production unit outlet connected to a liquid product tap;

transporting an amount of the liquid product from the mixing chamber to the production unit outlet; and

withdrawing an amount of the liquid product from the production unit by means of the liquid production tap.

22. The method of claim 16, further comprising the steps of:

providing a production unit outlet connected to one or more fluid containers, and

supplying an amount of the liquid product from the production unit to one or more of the fluid containers.

23. The method of claim 16, further comprising the step of producing the liquid product as a batch or continuously, and/or the step of producing the liquid product on demand.

24. The method of claim 16, further comprising the step of controlling the production unit to produce the liquid product in dependence on the consumption of the liquid product by the sample processing apparatus.

26. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 16.

27. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 17.

28. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 18.

29. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 19.

30. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 20.

31. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 21.

32. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 22.

33. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 23.

34. A computer-readable medium that stores computer program parts, which when executed by a processor controls steps in a method according to claim 24.

25. (canceled)