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TOXIN PEPTIDE THERAPEUTIC AGENTS

  • US 20110045587A1
  • Filed: 11/02/2010
  • Published: 02/24/2011
  • Est. Priority Date: 04/22/2005
  • Status: Active Grant
First Claim
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1. A DNA encoding a composition of matter for extending the half-life of a polypeptide, of the formula
(X1)a

  • (F1)d

    (X2)b

    (F2)e

    (X3)c or multimers thereof, wherein;

    F1 and F2 are half-life extending moieties selected from;

    (i) a human IgG Fc domain or a portion thereof,(ii) a transthyretin protein domain, and(iii) a human serum albumin (HSA) protein domain;

    and d and e are each independently 0 or 1, provided that at least one of d and e is 1;

    X1, X2, and X3 are each independently -(L)f-P-(L)g-, and f and g are each independently 0 or 1;

    P is a polypeptide of no more than about 80 amino acid residues in length, comprising the amino acid sequence of SEQ ID NO;

    914, SEQ ID NO;

    915, SEQ ID NO;

    916, or SEQ ID NO;

    917;

    L is a linker; and

    a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1.

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