CANDIDATE GENES AND BLOOD BIOMARKERS FOR BIPOLAR MOOD DISORDER, ALCOHOLISM AND STRESS DISORDER
First Claim
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1. A method of diagnosing bipolar disorder, alcoholism and/or stress disorder in an individual, the method comprising:
- determining the level of a plurality of biomarkers for the disorders in a sample from the individual, the plurality of biomarkers selected from the group consisting of biomarkers listed in Table 4 and/or Table 5 and/or 6.
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Abstract
Analysis of the gene expression changes identified a series of novel candidate genes and blood biomarkers for bipolar disorder, alcoholism and stress disorder. These are used for diagnosing the disorders, predicting and monitoring response to treatment. A novel treatment for these co-morbid disorders, DHA (Docosahexaenoic acid—an omega-3 fatty acid) was identified, using these genes and biomarkers, as well as the transgenic animal model.
7 Citations
26 Claims
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1. A method of diagnosing bipolar disorder, alcoholism and/or stress disorder in an individual, the method comprising:
determining the level of a plurality of biomarkers for the disorders in a sample from the individual, the plurality of biomarkers selected from the group consisting of biomarkers listed in Table 4 and/or Table 5 and/or 6. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 16)
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11. A method of predicting the probable course and outcome (prognosis) of bipolar disorder, alcoholism and/or stress disorder in a subject, the method comprising:
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analyzing a test sample from a subject, wherein the subject is suspected of having bipolar disorder, alcoholism and/or stress disorder for the presence or level of a plurality of biomarkers, wherein the markers are selected from the group consisting of biomarkers listed in Tables 4-6 and thereby determining the prognosis of the subject based on the presence or level of the biomarkers and one or more clinicopathological data to implement a particular treatment plan for the subject. - View Dependent Claims (12, 13)
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14. (canceled)
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17. A method for clinical screening of agents capable of affecting bipolar disorder, alcoholism and/or stress disorder, the method comprising:
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(a) administering a candidate agent to a population of individuals suspected of suffering from bipolar disorder, alcoholism and/or stress disorder; (b) monitoring the expression profile of one or more of the biomarkers listed in Tables 4-5 in blood samples obtained from the individuals receiving the candidate agent compared to a control group; and (c) determining that the candidate agent is capable of affecting bipolar disorder, alcoholism and/or stress disorder based on the expression profile of one or more of the biomarkers in the blood samples obtained from the individuals receiving the candidate drug compared to the control. - View Dependent Claims (18, 19)
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- 20. A diagnostic microarray for bipolar disorder, alcoholism and/or stress disorder comprising a plurality of nucleic acid molecules representing genes selected from the group of genes listed in Tables 4-6.
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21. (canceled)
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23. (canceled)
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24. (canceled)
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25. (canceled)
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26. (canceled)
Specification