RNA-Induced Translational Silencing and Cellular Apoptosis
First Claim
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1. A method of inducing apoptosis or inhibiting protein synthesis in a population of cells, comprising administering to said cells an effective amount of an RNA molecule 18-35 nucleotides in length, wherein said RNA molecule has a sequence that is at least 90% identical to a sequence found within the first 40 nucleotides at the 5′
- end of a human tRNA.
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Abstract
The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatological growths and viral infections.
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Citations
42 Claims
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1. A method of inducing apoptosis or inhibiting protein synthesis in a population of cells, comprising administering to said cells an effective amount of an RNA molecule 18-35 nucleotides in length, wherein said RNA molecule has a sequence that is at least 90% identical to a sequence found within the first 40 nucleotides at the 5′
- end of a human tRNA.
- View Dependent Claims (8, 10, 12, 13, 14)
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2-7. -7. (canceled)
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9. (canceled)
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11. (canceled)
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15. A pharmaceutical composition comprising 0.0001-10 weight percent (wt %) of an RNA molecule 18-35 nucleotides in length, wherein said RNA comprises a sequence that is at least 90% identical to a sequence within the group consisting of:
- SEQ ID NO;
1-SEQ ID NO;
132 as shown in Table 1 together with one or more excipients. - View Dependent Claims (16, 20, 21, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
- SEQ ID NO;
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17-19. -19. (canceled)
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22-32. -32. (canceled)
Specification