COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS

• US 20110046211A1
• Filed: 10/27/2010
• Published: 02/24/2011
• Est. Priority Date: 09/30/2004
• Status: Abandoned Application

• Current Assignee: University of Chicago
• Original Assignee: University of Chicago
• Inventors: Du, Wei, Weichselbaum, Ralph R., Shafaee, Zahra
• Application Number:
  US12/913,459
• Publication Number:
  US 20110046211A1
• Time in Patent Office: Days
• US Class Current: 514/449
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/4355 the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61K 31/7068 having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.

Claims

1-41. -41. (canceled)

42. A method of inhibiting growth of cancer cells expressing the hedgehog signaling pathway comprising, contacting the cells with effective amounts of a hedgehog inhibitor and an antimicrotubule chemotherapeutic agent to inhibit the growth of the cells.

53. A method of enhancing the antiproliferative effect of chemotherapy against cells expressing the hedgehog signaling pathway in a mammalian patient comprising, co-administering to the patient therapeutically effective amounts of a hedgehog inhibitor and an antimicrotubule chemotherapeutic agent to enhance the antiproliferative effect of the chemotherapy.

56. A method of inhibiting abnormal growth of cells expressing the hedgehog signaling pathway in a mammalian patient comprising, co-administering therapeutically effective amounts of a hedgehog inhibitor and an antimicrotubule chemotherapeutic agent to inhibit the abnormal growth of the cells.