COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS
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Abstract
The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.
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Citations
56 Claims
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1-41. -41. (canceled)
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42. A method of inhibiting growth of cancer cells expressing the hedgehog signaling pathway comprising, contacting the cells with effective amounts of a hedgehog inhibitor and an antimicrotubule chemotherapeutic agent to inhibit the growth of the cells.
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53. A method of enhancing the antiproliferative effect of chemotherapy against cells expressing the hedgehog signaling pathway in a mammalian patient comprising, co-administering to the patient therapeutically effective amounts of a hedgehog inhibitor and an antimicrotubule chemotherapeutic agent to enhance the antiproliferative effect of the chemotherapy.
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56. A method of inhibiting abnormal growth of cells expressing the hedgehog signaling pathway in a mammalian patient comprising, co-administering therapeutically effective amounts of a hedgehog inhibitor and an antimicrotubule chemotherapeutic agent to inhibit the abnormal growth of the cells.
Specification