PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OF OVERDOSE OR ABUSE
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Abstract
The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause overdose or to be abused. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.
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Citations
80 Claims
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1-61. -61. (canceled)
- 62. A method of treating attention deficit hyperactivity disorder in a patient in need thereof, comprising orally administering an effective amount of an amphetamine (1-phenylpropan-2-amine) covalently bound to a chemical moiety, wherein the chemical moiety is a non-standard amino acid, the amino acid is bound through its C-terminus to the amino group of the amphetamine, and the bound amphetamine maintains a steady-state serum release curve which provides a therapeutically effective bioavailability of the amphetamine.
- 74. A method of treating attention deficit hyperactivity disorder in a patient in need thereof, comprising orally administering an effective amount of an amphetamine (1-phenylpropan-2-amine) covalently bound to a chemical moiety, wherein the chemical moiety is a non-standard amino acid and the amino acid is bound through its C-terminus to the amino group of the amphetamine.
Specification