METHODS FOR CONCOMITANT ADMINISTRATION OF COLCHICINE AND A SECOND ACTIVE AGENT
First Claim
1. A method of treating a patient with colchicine, comprisingorally administering an adjusted daily dosage amount of colchicine to the patient who is receiving concomitant administration of a daily dose of atorvastatin, wherein the atorvastatin is administered to treat an atorvastatin-responsive condition,wherein the adjusted daily dosage amount of colchicine is about 50% to 75% of an intended daily dosage amount of colchicine, andwherein the intended daily dosage amount of colchicine is a daily dosage amount suitable for the patient if the patient were not receiving concomitant atorvastatin, wherein concomitant administration of atorvastatin is administration either simultaneously with colchicine or within a time period during which the effects of the colchicine are still operative in the patient.
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Accused Products
Abstract
Methods for concomitant administration of colchicine together with one or more second active agents, e.g., atorvastatin, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.
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Citations
13 Claims
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1. A method of treating a patient with colchicine, comprising
orally administering an adjusted daily dosage amount of colchicine to the patient who is receiving concomitant administration of a daily dose of atorvastatin, wherein the atorvastatin is administered to treat an atorvastatin-responsive condition, wherein the adjusted daily dosage amount of colchicine is about 50% to 75% of an intended daily dosage amount of colchicine, and wherein the intended daily dosage amount of colchicine is a daily dosage amount suitable for the patient if the patient were not receiving concomitant atorvastatin, wherein concomitant administration of atorvastatin is administration either simultaneously with colchicine or within a time period during which the effects of the colchicine are still operative in the patient.
Specification