Non-Invasive Patient Monitoring Using Near Infrared Spectrophotometry
First Claim
1. A method for non-invasive spectrophotometric monitoring of an optical property of a medium, comprising:
- securing each of a first optical source, a second optical source, a first optical detector, and a second optical detector to a surface of the medium;
during each of a calibration interval and a monitoring interval, said monitoring interval being subsequent to said calibration interval, propagating a first portion of light from the first optical source through the medium to the first optical detector, a second portion of light from the second optical source through the medium to the first optical detector, a third portion of light from the first optical source through the medium to the second optical detector, and a fourth portion of light from the second optical through the medium to the second optical detector;
processing detections of said first, second, third, and fourth light portions acquired during said calibration time interval to compute at least one algorithm compensation that causes a first result related to said optical property based on said first and second detected light portions to be substantially equal to a second result related to said optical property based on said third and fourth detected light portions; and
processing detections of said first, second, third, and fourth light portions acquired during said monitoring interval in conjunction with said at least one algorithm compensation to compute a monitoring result for the optical property of the medium.
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Accused Products
Abstract
Methods, systems, and related computer program products for non-invasive spectrophotometric monitoring of an optical property of a medium are described. Respective light portions are propagated through respective at least partially non-overlapping subregions of the medium during each of a calibration interval and a subsequent monitoring interval. Detections of the light portions acquired during the calibration interval are processed to compute at least one algorithm compensation that causes a first result related to the optical property for the first subregion to be substantially equal to a second result related to the optical property for the second subregion. Subsequently, detections of respective light portions acquired during the monitoring interval are processed in conjunction with the at least one algorithm compensation to compute a monitoring result for the optical property. Advantages can include a reduction in the number of sources/detectors required and/or an obviation of symmetry requirements in source/detector layout.
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Citations
26 Claims
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1. A method for non-invasive spectrophotometric monitoring of an optical property of a medium, comprising:
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securing each of a first optical source, a second optical source, a first optical detector, and a second optical detector to a surface of the medium; during each of a calibration interval and a monitoring interval, said monitoring interval being subsequent to said calibration interval, propagating a first portion of light from the first optical source through the medium to the first optical detector, a second portion of light from the second optical source through the medium to the first optical detector, a third portion of light from the first optical source through the medium to the second optical detector, and a fourth portion of light from the second optical through the medium to the second optical detector; processing detections of said first, second, third, and fourth light portions acquired during said calibration time interval to compute at least one algorithm compensation that causes a first result related to said optical property based on said first and second detected light portions to be substantially equal to a second result related to said optical property based on said third and fourth detected light portions; and processing detections of said first, second, third, and fourth light portions acquired during said monitoring interval in conjunction with said at least one algorithm compensation to compute a monitoring result for the optical property of the medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for non-invasive spectrophotometric monitoring of an optical property of a medium, comprising:
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securing each of a first optical source, a second optical source, a first optical detector, and a second optical detector to a surface of the medium, each being secured at a different one of a first location, a second location, a third location, and a fourth location on said surface, wherein said first and second optical sources are secured at either (i) said first and fourth locations, respectively, or (ii) said second and third locations, respectively; during each of a calibration interval and a monitoring interval, said monitoring interval being subsequent to said calibration interval, propagating a first portion of light through the medium between said first and second locations, a second portion of light through the medium between said first and third locations, a third portion of light through the medium between said second and fourth locations, and a fourth portion of light through the medium between said third and fourth locations; processing detections of said first, second, third, and fourth light portions acquired during said calibration time interval to compute at least one algorithm compensation that causes a first result related to said optical property based on said first and second detected light portions to be substantially equal to a second result related to said optical property based on said third and fourth detected light portions; and processing detections of said first, second, third, and fourth light portions acquired during said monitoring interval in conjunction with said at least one algorithm compensation to compute a monitoring result for the optical property of the medium. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An apparatus for non-invasive spectrophotometric monitoring of an optical property of a tissue volume of a patient, comprising:
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a probe patch wearable on a surface of the tissue volume of the patient during each of a calibration interval and a monitoring interval, the probe patch comprising a first optical source, a second optical source, a first optical detector, and a second optical detector each positioned at a different one of a first location, a second location, a third location, and a fourth location on a surface-facing side of the probe patch, wherein said first and second optical sources are secured at either (i) said first and fourth locations, respectively, or (ii) said second and third locations, respectively, said probe patch being configured to propagate a first portion of light through the medium between said first and second locations, a second portion of light through the medium between said first and third locations, a third portion of light through the medium between said second and fourth locations, and a fourth portion of light through the medium between said third and fourth locations; a calibration processor configured to process detections of said first, second, third, and fourth light portions acquired during said calibration time interval and to determine therefrom at least one algorithm compensation that causes a first result related to said optical property based on said first and second detected light portions to be substantially equal to a second result related to said optical property based on said third and fourth detected light portions; a monitoring processor configured to process detections of said first, second, third, and fourth light portions acquired during said monitoring interval in conjunction with said at least one algorithm compensation to compute a monitoring result for the optical property of the medium; and a display device coupled to said monitoring processor for displaying said monitoring result during said monitoring session. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification