TECHNIQUES FOR CORRECTING TEMPERATURE MEASUREMENT IN MAGNETIC RESONANCE THERMOMETRY

• US 20110046475A1
• Filed: 08/24/2009
• Published: 02/24/2011
• Est. Priority Date: 08/24/2009
• Status: Abandoned Application

• Current Assignee: General Electric Company, InSightec Ltd.
• Original Assignee: General Electric Company, InSightec Ltd.
• Inventors: Assif, Benny, Mallozzi, Richard P., Dumoulin, Charles L., Darrow, Robert D.
• Application Number:
  US12/546,269
• Publication Number:
  US 20110046475A1
• Time in Patent Office: Days
• US Class Current: 600/422
• CPC Class Codes: G01R 33/24 for measuring direction or magnitude of magnetic fields or magnetic flux
• CPC Class Codes: G01R 33/243 Spatial mapping of the polarizing magnetic field
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/4814 MR combined with ultrasound
• CPC Class Codes: G01R 33/565 Correction of image distortions, e.g. due to magnetic field inhomogeneities
• CPC Class Codes: G01R 33/56509 due to motion, displacement or flow, e.g. gradient moment nulling G01R33/567 takes precedence
• CPC Class Codes: G01R 33/56563 caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0 G01R33/56509, G01R33/56518, G01R33/56536 take precedence
• CPC Class Codes: G01R 33/58 Calibration of imaging systems, e.g. using test probes , Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material

Abstract

Techniques for correcting temperature measurement in MR thermometry are disclosed. In particular, phase shifts that arise from factors other than temperature changes are detected, facilitating correction of temperature measurements.

Claims

1. A method of correcting proton resonance frequency (PRF) based magnetic resonance (MR) temperature measurement, the method comprising the steps of:

detecting at least one first MR response of one or more micro-coils located in or near a region of interest, the detection being performed approximately when a first PRF image of the region of interest is acquired;

detecting at least one second MR response of the one or more micro-coils approximately when a second PRF image of the region of interest is acquired;

determining a temperature-invariant difference between the at least one second MR response and the at least one first MR response, the temperature-invariant difference being caused by factors unrelated to a temperature change in or near the region of interest; and

correcting, based on the temperature-invariant difference, a temperature measurement of the region of interest made from the second PRF image and the first PRF image.

2. The method of claim 1, wherein (i) the one or more micro-coils consist of a single micro-coil, and (ii) the temperature-invariant difference determined from the at least one second MR response and the at least one first MR response of the single micro-coil provides a spatially uniform correction to the first PRF image.

3. The method of claim 1, wherein (i) the one or more micro-coils consist of four micro-coils arranged in a non-coplanar fashion, and (ii) the temperature-invariant difference determined from the at least one second MR response and the at least one first MR response of the four micro-coils provides a zero-th order and a first order corrections to the first PRF image.

4. The method of claim 1, wherein (i) the one or more micro-coils consist of five or more micro-coils arranged in a non-coplanar fashion, and (ii) the temperature-invariant difference determined from the at least one second MR response and the at least one first MR response of the five or more micro-coils provides a zero-th order, a first order, and at least a partial second order corrections to the first PRF image.

5. The method of claim 1, wherein the one or more micro-coils are filled with a substance that provides temperature-insensitive MR responses.

6. The method of claim 5, wherein the one or more micro-coils are filled with oil or other non-aqueous fluid.

7. The method of claim 1, wherein the one or more micro-coils are filled with water or water-based substance, and wherein temperature(s) at the locations of the micro-coil(s) are constant.

8. The method of claim 1, wherein the one or more micro-coils are filled with water or water-based substance and temperature(s) at the locations of the micro-coil(s) are known, and further comprising adjusting for a temperature-dependent component of the second MR response in determining the temperature-invariant difference between the at least one second MR response and the at least one first MR response.

9. The method of claim 1, further comprising:

independently determining temperature(s) at the locations of the micro-coil(s) with a non-MR-based method; and

calculating the temperature-invariant difference between the second MR response and the first MR response based at least in part on the determined temperature(s).

10. The method of claim 1, further comprising:

determining a local PRF image change in or near the region of interest based on the detection of the at least one first MR response and the detection of the at least one second MR response, the local PRF image change being correlated to a local magnetic field.

11. The method of claim 1, further comprising:

determining a local magnetic field in or near the region of interest, based on the detection of the at least one first MR response and/or the detection of the at least one second MR response, according to one or more of;

(a) an MR tracking method of detecting four MR responses from each of one or more micro-coils and then calculating coordinates of each of one or more micro-coils and the local magnetic field based on the detected MR responses;

or

(b) a spectral acquisition method of detecting one MR response from each of the one or more micro-coils in the absence of an applied magnetic field gradient and then calculating the local magnetic field based on the detected MR responses without calculating the coordinates of the one or more micro-coils;

or

(c) a phase-sensitive acquisition method of detecting a change in PRF phase images correlated with the local magnetic field change;

or

(d) an MR imaging method of acquiring one or more MR images wherein each scan plane includes the one or more micro-coils;

or

(e) a hybrid method combining at least two of (a), (b), (c) or (d).

12. The method of claim 1, further comprising:

correcting the first PRF image based on the determined temperature-invariant difference, such that the corrected first PRF image provides an updated baseline reference for the second PRF phase image.

13. The method of claim 1, further comprising:

determining MR shim currents from at least one of the at least one first MR response and the at least one second MR response; and

determining a change in magnetic field based on the MR shim currents.

14. The method of claim 1, further comprising:

correcting the second PRF image based on the determined temperature-invariant difference, such that the temperature measurement is less affected by magnetic field changes unrelated to the temperature change.

15. The method of claim 1, wherein the temperature measurement comprises an MR thermal image or temperature map.

16. A system for correcting proton resonance frequency (PRF) based magnetic resonance (MR) temperature measurement, the system comprising:

an MRI unit;

one or more micro-coils configured to generate MR response signals in response to the MRI unit, the one or more micro-coils being sufficiently small to be placed in or near a region of interest;

a control module in communication with the MRI unit and the one or more micro-coils, and configured to;

cause at least one first MR response of the one or more micro-coils to be detected approximately when the MRI unit acquires a first PRF image of the region of interest, and

cause at least one second MR response of the one or more micro-coils to be detected approximately when the MRI unit acquires a second PRF image of the region of interest; and

a processing module configured to;

determine a temperature-invariant difference between the at least one second MR response and the at least one first MR response, the temperature-invariant difference being caused by factors unrelated to a temperature change in or near the region of interest, and

correct, based on the temperature-invariant difference, a temperature measurement of the region of interest made from the second PRF image and the first PRF image.

17. The system of claim 16, wherein (i) the one or more micro-coils consist of a single micro-coil, and (ii) the temperature-invariant difference determined from the at least one second MR response and the at least one first MR response of the single micro-coil provides a spatially uniform correction to the first PRF image.

18. The system of claim 16, wherein (i) the one or more micro-coils consist of four micro-coils arranged in a non-coplanar fashion, and (ii) the temperature-invariant difference determined from the at least one second MR response and the at least one first MR response of the four micro-coils provides a zero-th order and a first order corrections to the first PRF image.

19. The system of claim 16, wherein (i) the one or more micro-coils consist of five or more micro-coils arranged in a non-coplanar fashion, and (ii) the temperature-invariant difference determined from the at least one second MR response and the at least one first MR response of the five or more micro-coils provides a zero-th order, a first order, and at least a partial second order corrections to the first PRF image.

20. The system of claim 16, wherein the one or more micro-coils are filled with a substance that provides temperature-insensitive MR responses.

21. The system of claim 20, wherein the one or more micro-coils are filled with oil or other non-aqueous fluid.

22. The system of claim 16, wherein the one or more micro-coils are filled with water or water-based substance, and wherein temperature(s) at the locations of the micro-coil(s) are constant.

23. The system of claim 16, wherein:

(i) the one or more micro-coils are filled with water or water-based substance and temperature(s) at the locations of the micro-coil(s) are known, and (ii) the processing module is further configured to adjust for a temperature-dependent component of the second MR response in determining the temperature-invariant difference between the at least one second MR response and the at least one first MR response.

24. The system of claim 16, further comprising:

one or more front-end signal processors to receive the MR response signals from the one or more micro-coils.

25. The system of claim 16, further comprising:

tuning and matching capacitors coupled to the one to or more micro-coils to improve signal-to-noise ratio of the MR response signals.

26. The system of claim 16, further comprising:

decoupling circuitry to disable the one or more micro-coils during an operation of the MRI unit.

27. The system of claim 16, further comprising:

at least one temperature sensor to independently monitor temperatures at the locations of the one or more micro-coils.

28. A computer-readable medium storing computer-executable codes for causing at least one processor to correct proton resonance frequency (PRF) based magnetic resonance (MR) temperature measurement, the computer readable medium comprising:

computer-executable code adapted to detect at least one first MR response of one or more micro-coils located in or near a region of interest, the detection being performed approximately when a first PRF image of the region of interest is acquired;

computer-executable code adapted to detect at least one second MR response of the one or more micro-coils approximately when a second PRF image of the region of interest is acquired;

computer-executable code adapted to determine a temperature-invariant difference between the at least one second MR response and the at least one first MR response, the temperature-invariant difference being caused by factors unrelated to a temperature change in or near the region of interest; and

computer-executable code adapted to correct, based on the temperature-invariant difference, a temperature measurement of the region of interest made from the second PRF image and the first PRF image.

29. The computer-readable medium of claim 28, further comprising:

computer-executable code adapted to independently determine temperature(s) at the locations of the micro-coil(s) with a non-MR-based method; and

computer-executable code adapted to calculate the temperature-invariant difference between the second MR response and the first MR response based at least in part on the determined temperature(s).

30. The computer-readable medium of claim 28, further comprising:

computer-executable code adapted to determine a local PRF image change in or near the region of interest based on the detection of the at least one first MR response and the detection of the at least one second MR response, the local PRF image change being correlated to a local magnetic field.

31. The computer-readable medium of claim 28, further comprising:

computer-executable code adapted to determine a local magnetic field in or near the region of interest, based on the detection of the at least one first MR response and/or the detection of the at least one second MR response, according to one or more of;

(a) an MR tracking method of detecting four MR responses from each of one or more micro-coils and then calculating coordinates of each of one or more micro-coils and the local magnetic field based on the detected MR responses;

or

(b) a spectral acquisition method of detecting one MR response from each of the one or more micro-coils in the absence of an applied magnetic field gradient and then calculating the local magnetic field based on the detected MR responses without calculating the coordinates of the one or more micro-coils;

or

(c) a phase-sensitive acquisition method of detecting a change in PRF phase images correlated with the local magnetic field change;

or

(d) an MR imaging method of acquiring one or more MR images wherein each scan plane includes the one or more micro-coils;

or

(e) a hybrid method combining at least two of (a), (b), (c) or (d).

32. The computer-readable medium of claim 28, further comprising:

computer-executable code adapted to correct the first PRF image based on the determined temperature-invariant difference, such that the corrected first PRF image provides an updated baseline reference for the second PRF phase image.

33. The computer-readable medium of claim 28, further comprising:

computer-executable code adapted to determine MR shim currents from at least one of the at least one first MR response and the at least one second MR response; and

computer-executable code adapted to determine a change in magnetic field based on the MR shim currents.

34. The computer-readable medium of claim 28, further comprising:

computer-executable code adapted to correct the second PRF image based on the determined temperature-invariant difference, such that the temperature measurement is less affected by magnetic field changes unrelated to the temperature change.