IMPLANTABLE HEART STIMULATOR DETERMINING LEFT VENTRICULAR SYSTOLIC PRESSURE

• US 20110046691A1
• Filed: 06/18/2008
• Published: 02/24/2011
• Est. Priority Date: 06/18/2008
• Status: Abandoned Application

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Järverud, Karin, Björling, Anders, Blomqvist, Andreas
• Application Number:
  US12/990,136
• Publication Number:
  US 20110046691A1
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

An implantable heart stimulator has an impedance measurement a cardiogenic impedance waveform using an impedance configuration arranged to measure myocardial contractility of the heart. The heart stimulator further has a calculating unit that calculates an estimate value being related to at least two impedance values of the waveform, or of an average waveform of several consecutive waveforms, during a predetermined time period of the waveform, or average waveform, the calculated estimate value being an estimate of the left ventricular (LV) systolic pressure.

Claims

1-16. -16. (canceled)

17. An implantable heart stimulator comprising:

an impedance measurement circuit that measures and determines a cardiogenic impedance waveform with an impedance configuration that measures myocardial contractility of the heart; and

a calculating unit supplied with said cardiogenic impedance waveform, said calculating unit being configured to calculate an estimate of left ventricular systolic pressure of said heart from two impedance values of said cardiogenic impedance waveform, selected from the group consisting of at least two impedance values of a single waveform, and at least two impedance values of an average waveform of a plurality of consecutive waveforms, during a predetermined time period of said cardiogenic impedance waveform, and to emit the calculated estimate value as an output from said calculating unit.

18. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit is configured to calculate said estimate value as a difference between said at least two impedance values.

19. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit selects said at least two impedance values respectively at a beginning and an end of said predetermined time period.

20. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit selects said at least two impedance values as the minimum impedance value that occurs during said predetermined time period, and an impedance value at an end of said predetermined time period, respectively.

21. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit is configured to calculate an estimated left ventricular systolic pressure by integrating a rate of change of said waveform during said time period.

22. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit is configured to select said predetermined time period during an early systolic portion of said waveform.

23. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit is configured to determine said predetermined time period as a time period initiated by an R-wave and terminated by a subsequent aortic valve opening.

24. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit is configured to determine said predetermined time period as a time period initiated by an R-wave and lasting for a time duration thereafter in a range between 50 and 200 ms.

25. An implantable heart stimulator as claimed in claim 17 wherein said calculating unit is configured to determine said predetermined time period as a time window initiated by an R-wave and terminating when an impedance value Z_max is maximum, a time when Z_max occurs being determined by morphology analysis of said cardiogenic impedance signal to identify said maximum value and a corresponding point in time.

26. An implantable heart stimulator as claimed in claim 17 wherein said calculator employs said average waveform as said cardiogenic impedance waveform, and calculates said average waveform from detected cardiogenic impedance waveforms during at least one complete respiration cycle.

27. An implantable heart stimulator as claimed in claim 17 comprising a memory in which successively calculated left ventricular systolic pressures emitted from said calculating unit are stored, and a processor having access to said memory configured to calculate a trend represented by the respective left ventricular systolic pressures stored in said memory.

28. An implantable heart stimulator as claimed in claim 17 wherein said impedance measurement circuit is a first impedance measurement circuit, and comprising a second impedance measurement circuit that determines at least one cardiac stroke volume parameter indicative of the stroke volume of the heart, and wherein said calculating unit is configured to calculate stroke work of the heart based on a product of said measured cardiac stroke volume parameter and the estimated left ventricular systolic pressure.

29. An implantable heart stimulator as claimed in claim 28 wherein said heart stimulator comprises a therapy unit configured to administer stimulation therapy to the heart according to settings, and comprising a computerized control unit supplied with the calculated stroke work, said computerized control unit being configured to optimize said settings dependent on the calculated stroke work to maximize the stroke work of the heart.

30. An implantable heart stimulator as claimed in claim 29 comprising a stimulation therapy administration circuit comprising at least one therapy-administering electrode lead, exhibiting a lead position, and comprising a computerized control unit that controls said therapy administration circuit dependent on the calculated stroke work to optimize said lead position.

31. An implantable heart stimulator as claimed in claim 29 comprising a memory in which the calculated stroke work, calculated at respectively different times, is stored, and a processor having access to said memory configured to determine a trend represented by the calculated stroke work at said different times stored in said memory.

32. An implantable heart stimulator as claimed in claim 31 wherein said processor is configured to trend the calculate stroke work over time at a predetermined level of activity of a patient.