Method for Managing Obesity, Diabetes and Other Glucose-Spike-Induced Diseases

• US 20110047108A1
• Filed: 07/06/2010
• Published: 02/24/2011
• Est. Priority Date: 08/21/2009
• Status: Active Grant

• Current Assignee: Neilin Chakrabarty, Tapantosh Chakrabarty
• Original Assignee: Neilin Chakrabarty, Tapantosh Chakrabarty
• Inventors: Chakrabarty, Tapantosh, Chakrabarty, Neilin
• Granted Patent: US 8,589,082 B2
• Time in Patent Office: Days
• US Class Current: 706/14
• CPC Class Codes: G16H 10/65 stored on portable record carriers, e.g. on smartcards, RFID tags or CD
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

Disclosed is a method for managing obesity, diabetes, hair loss, aging, cardiovascular, or other blood glucose-spike-induced diseases by reducing the post-prandial blood glucose spike, or the glucose shock. The blood glucose spike, or the glucose shock is reduced by generating a person-specific glucose profile for at least one significant meal to tune or train a blood glucose model (kinetic, artificial intelligence or hybrid), and then using the tuned or the trained model embedded in a computation-capable electronic device to compute and recommend a person-specific meal plan and an exercise plan, including semi-continuous meal ingestion and post-meal exercise while sitting at home or office. Advantages over prior art are that the method uses less strenuous exercise with no or less medicine, is person-specific, quantitative and more suitable for use by an individual, a dietician, or a health care practitioner.

Claims

1. A method for lowering the risk of developing blood-glucose-spike-induced diseases, or for managing the said diseases, if already developed, the method comprising the steps of:

a) generating, through measurements, a person-specific profile of glucose concentration vs. time for at least one significant meal, the profile indicating the timing and the amplitude of the glucose spike;

b) tuning or training a blood glucose response model with the measured person-specific blood glucose profile data for at least one meal;

c) using the tuned or the trained blood glucose response model to develop at least one significant meal plan and a post-prandial exercise plan, needed for reducing the post-prandial glucose spike, or the glucose shock, defined by the increase in area over the pre-meal area under the blood glucose concentration vs. time plot, to a respective target level; and

d) executing the meal and/or the post-prandial exercise plan and comparing the measured blood glucose spike, or the glucose shock with a target range to assess the success of the glucose spike reduction plan, and readjusting, if necessary, the meal and/or the post-prandial exercise plan using the tuned or trained blood glucose response model.

2. A method according to claim 1, wherein the blood glucose response model is a kinetic model for the reactions of carbohydrates to glucose to glucose uptake by cells:

C→

G→

GL(and E)

that yields a mathematical expression for the blood glucose level at any time t since taking a meal, the said expression obtained by integrating and algebraically manipulating the rate equations for the said reactions, and is given by the equation below;

3. A method according to claim 1, wherein the blood glucose response model is an artificial intelligence model, or a hybrid model comprising a kinetic model and an artificial intelligence model.

4. A method according to claim 1, wherein a computer, a Smartphone or a glucose level monitor is used for storing of personal blood glucose profile and blood glucose response model, tuning or training of the said model with the personal blood glucose profile, and computing and displaying of the meal and exercise plans.

5. A method according to claim 1, wherein the meal comprises foods with low glycemic indices (GI) and low glycemic loads (GL), meeting the daily recommended carbohydrates and protein needs.

6. A method according to claim 1, wherein the post-prandial blood glucose spike is reduced to be not more than 2 to 5 mmol/L above the pre-meal blood glucose level, or the glucose shock is reduced by at least 20% over that before following the method.

7. A method according to claim 1, wherein the post-prandial exercise plan includes body movement, forward or backward walking, forward or backward running, weight training, dancing, using a vibration machine, a tread mill, an elliptical machine or a rowing machine, spot running, stair climbing, or any other suitable form of physical activity.

8. A method according to claim 1, wherein the post-prandial exercise is performed by using a leg exercise machine that allows up and down, circular, or elliptical movement of the legs, or by using a vibration machine, each machine used while sitting on a chair at home or at work.

9. A method according to claim 1, wherein the post-prandial exercise is commenced at a time, t (counted from the time the most recent significant meal has been taken), which falls between (tspike−

x) and (tspike+y), where x is 15 to 30 minutes and y is 15 to 60 minutes.

10. A method according to claim 1, wherein at least one significant meal is taken semi-continuously by splitting the meal into more than one portion and taking each portion at a different time.

11. A method according to claim 1, wherein at least one significant meal is taken semi-continuously as a liquid by sipping it from a bottle.

12. A method according to claim 1, wherein the time, t, between two consecutive split meals is:

30 minutes<

t minutes<

120 minutes.

13. A method according to claim 1, wherein the tuned- or the trained-model-recommended meal and exercise plans are used without or with any alternative medicine or prescribed medicine, including insulin.

14. A method according to claim 1, wherein the blood glucose spike, or the glucose shock is reduced to lower the risk of developing obesity, or if already developed, to manage obesity.

15. A method according to claim 1, wherein the blood glucose spike, or the glucose shock is reduced to lower the risk of developing abdominal fat, or if already developed, to reduce abdominal fat.

16. A method according to claim 1, wherein the blood glucose spike, or the glucose shock is reduced to lessen hair loss.

17. A method according to claim 1, wherein the blood glucose spike, or the glucose shock is reduced to lower the risk of developing pre-diabetes, Type 2 diabetes, or to manage pre-diabetes, Type 1 or 2 diabetes, or if already developed, to manage the said diseases.

18. A method according to claim 1, wherein the blood glucose spike, or the glucose shock is reduced to manage hypoglycemia.

19. A method according to 1, wherein the blood glucose spike, or the glucose shock is reduced to assuage aging-associated cognitive decline or dementia, or lower the risk of developing Alzheimer'"'"'s disease.

20. A method according to claim 1, wherein the blood glucose spike, or the glucose shock is reduced to lower the risk of developing cardiovascular diseases, nephropathy, neuropathy, retinopathy, or cancer.