COMPOSITIONS COMPRISING BASIC AMINO ACID AND SOLUBLE CARBONATE SALT

• US 20110052509A1
• Filed: 02/06/2009
• Published: 03/03/2011
• Est. Priority Date: 02/08/2008
• Status: Abandoned Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Sullivan, Richard J., Subramanyam, Ravi, Wu, Donghui, Simon, Eric A., Robinson, Richard Scott, Kohli, Rajnish
• Application Number:
  US12/866,644
• Publication Number:
  US 20110052509A1
• Time in Patent Office: Days
• US Class Current: 424/52
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to compositions comprising a basic amino acid free or salt form and a soluble carbonate or bicarbonate salt.

Claims

1. An oral care composition comprising a basic amino acid in free or salt form and a soluble carbonate salt, wherein a bicarbonate of the basic amino acid is formed in situ.

2. The oral care composition of claim 1 having a pH of from about 8.5 to about 9.5.

3. The oral care composition of claim 1, wherein the basic amino acid is arginine, lysine, citrullene, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, salts thereof and/or combinations thereof.

4. The oral care composition of claim 3, wherein the basic amino acid is arginine.

5. The oral care composition of claim 1, wherein the basic amino acid is present in an amount corresponding to about 1 wt. % to about 10 wt. % of the total composition weight.

6. The oral care composition of claim 1, wherein the soluble carbonate salt is selected from sodium carbonate, sodium bicarbonate, and mixtures thereof.

7. The oral care composition of claim 1, further comprising an effective amount of a fluoride ion source.

8. The oral care composition claim 1, further comprising an abrasive.

9. The oral care composition of claim 8 wherein the abrasive is selected from precipitated calcium carbonate, silica and mixtures thereof.

10. The oral care composition of claim 1, further comprising at least one surfactant.

11. The oral care composition of claim 1, further comprising at least one humectant.

12. The oral care composition of claim 1, further comprising an antibacterial agent.

13. The oral care composition of claim 1, further comprising a physiologically acceptable potassium salt in an amount effective to reduce dentinal sensitivity.

14. The oral care composition of claim 1, wherein the composition is toothpaste.

15. The oral care composition of claim 1, wherein the composition is a mouthwash.

27. A method comprising applying an effective amount of the oral care composition of claim 1 to the oral cavity of a subject in need thereof to:

(i) reduce or inhibit formation of dental caries,

(ii) reduce, repair or inhibit pre-carious lesions of the enamel,

(iii) reduce or inhibit demineralization and promote remineralization of the teeth,

(iv) reduce hypersensitivity of the teeth,

(v) reduce or inhibit gingivitis,

(vi) promote healing of sores or cuts in the mouth,

(vii) reduce levels of acid producing bacteria,

(viii) increase relative levels of arginolytic bacteria,

(ix) inhibit microbial biofilm formation in the oral cavity,

(x) raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge,

(xi) reduce plaque accumulation,

(xii) treat, relieve or reduce dry mouth,

(xiii) clean the teeth and oral cavity

(xiv) reduce erosion,

(xv) whiten teeth,

(xvi) immunize the teeth against cariogenic bacteria; and

/or

(xvii) promote systemic health, including cardiovascular health.

28. The oral care composition of claim 7, wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combination of two or more thereof.

29. The oral care composition of claim 13, wherein said potassium salt is selected from potassium nitrate and potassium chloride.

16. A method for preparing an oral care composition comprising a bicarbonate salt of a basic amino acid comprising mixing a basic amino acid in free or salt form and a soluble carbonate salt.

17. The method of claim 16 wherein the mixture comprises about 7 to about 10% wt, of the basic amino acid, weight being given as a free base.

18. The method of claim 16 wherein the carbonate salt is selected from sodium carbonate, sodium bicarbonate and mixtures thereof.

19. The method of claim 16 wherein the molar ratio of arginine to bicarbonate ion is about 4:

1 to about 1;

4.

20. The method of claim 16 wherein the composition is adjusted to about pH 9.

21. The method of claim 16 wherein the basic amino acid is selected from arginine, lysine, citrullene, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, salts thereof and/or combinations thereof.

22. The method of claim 21 wherein the basic amino acid is arginine in free or salt form or mixtures thereof.

23. The method of claim 22 wherein the arginine is initially provided in hydrochloride salt form.

24. The method of claim 16 further comprising adjusting the pH to about 8.5 to about 9.5.

25. The method of claim 24 wherein the oral care composition further comprises secondary materials are selected from the group consisting of a fluoride ion source, abrasives, surfactants, humectants, antibacterial agents, calcium salts, potassium salts, and combinations thereof.

26. An oral care composition prepared by the method of claim 16.

30. The method of claim 25, wherein at least one of said secondary materials is a fluoride ion source selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combination of two or more thereof.

31. The method of claim 25, wherein at least one of said secondary materials is a potassium salt selected from potassium nitrate and potassium chloride.