COMPOSITIONS AND METHODS FOR INHIBITING INTERLEUKIN PATHWAYS
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Abstract
Fusion proteins including an IL-17 receptor with a multimerization domain, or an IL-23 receptor and a multimerization domain, and recombinant viral vectors encoding such fusions, are described. The fusion proteins and vectors encoding such fusions, alone or in combination, can be used in methods for modulating the IL-17 and IL-23 signaling pathways and for treating or preventing diseases mediated by interleukin-17 and interleukin-23, such as immune-related and inflammatory diseases.
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Citations
55 Claims
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1-39. -39. (canceled)
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40. A fusion protein comprising:
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(a) an interleukin receptor or a portion thereof, wherein said interleukin receptor is selected from the group consisting of an IL-17 receptor and an IL-23 receptor which lacks an IL-12 receptor component; and (b) an immunoglobulin constant region multimerization domain, which is linked to the interleukin receptor or a portion thereof via a 5-25 amino acid residue linker. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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Specification