COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS
First Claim
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1. A method for determining the presence or absence of a cancer cell, the method comprising,contacting a sample comprising a cell with an agent that specifically binds with SEQ ID NO:
- 2; and
detecting binding of the agent to a polypeptide in the sample, wherein binding of the agent to the sample indicates the presence of a cancer cell.
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Abstract
Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
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Citations
17 Claims
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1. A method for determining the presence or absence of a cancer cell, the method comprising,
contacting a sample comprising a cell with an agent that specifically binds with SEQ ID NO: - 2; and
detecting binding of the agent to a polypeptide in the sample, wherein binding of the agent to the sample indicates the presence of a cancer cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 2; and
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10. A method of providing a diagnosis or prognosis of an individual having cancer, the method comprising detecting the presence or absence of expression of a polynucleotide encoding a CCX-CKR2 polypeptide in a cell of an individual, wherein the CCX-CKR2 polypeptide binds I-TAC and/or SDF1 and the CCX-CKR2 polypeptide is at least 95% identical to SEQ ID NO:
- 2, thereby diagnosing a cancer in the individual.
- View Dependent Claims (11, 12)
- 13. A method of treating cancer in an individual, the method comprising administering to the individual a therapeutically effective amount of an agent that competes with SDF1 and I-TAC for binding to SEQ ID NO:
Specification