CERAMIC SCAFFOLDS FOR BONE REPAIR
First Claim
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1. A method of making a ceramic article, comprising:
- a) forming at least one ceramic composition into a defined shape comprising at least two zones with different porosity or pore size, wherein a second said zone surrounds a first said zone in at least two dimensions, each said ceramic composition containing a ceramic material and a liquid;
b) exposing the shaped ceramic composition(s) to a solvent in which the liquid is soluble, to extract the liquid from and thereby harden said shaped ceramic composition(s); and
c) solidifying the resulting hardened ceramic composition(s) to provide the ceramic article.
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Abstract
Ceramic articles as functional biodegradable scaffolds with graded porosity are made by a process that includes a hardening step in which the liquid of a liquid-containing ceramic composition is extracted from the ceramic composition by exposing the ceramic composition to a solvent in which the liquid in the composition is soluble before the ceramic composition is solidified into the final ceramic article. An exemplary calcium phosphate porous ceramic article constructed in accordance with the process is useful as an implant to repair a bone defect.
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Citations
20 Claims
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1. A method of making a ceramic article, comprising:
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a) forming at least one ceramic composition into a defined shape comprising at least two zones with different porosity or pore size, wherein a second said zone surrounds a first said zone in at least two dimensions, each said ceramic composition containing a ceramic material and a liquid; b) exposing the shaped ceramic composition(s) to a solvent in which the liquid is soluble, to extract the liquid from and thereby harden said shaped ceramic composition(s); and c) solidifying the resulting hardened ceramic composition(s) to provide the ceramic article. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 19)
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12. A ceramic article comprising:
at least two zones comprising at least one ceramic material, wherein a second said zone surrounds a first said zone in at least two dimensions, at least two of said zones having different porosity or pore size, having solid struts between pores, and at least 70% pore interconnectivity. - View Dependent Claims (13, 14, 15, 16, 17, 18, 20)
Specification