Universal multi-variant detection system
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Abstract
The present invention provides a method to diagnostically detect the variants of a given pathogen, such as HIV, hepatitis C, hepatitis B (HBV), Parvovirus B19, etc., with the use of a single detection probe.
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Citations
70 Claims
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1-35. -35. (canceled)
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36. A kit for the detection of a target nucleic acid molecule in a sample, wherein the target nucleic acid molecule is known to have variant sequences, comprising:
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a set of nose-to-nose primers comprising a forward primer and a reverse primer; (ii) reagents for performing a primer extension chain reaction and; (iii) a self-altering signal-generating probe which detects the presence of primer amplification products, wherein the probe comprises a first nucleic acid sequence attached to a reporter moiety capable of generating a detectable signal;
a second nucleic acid sequence attached to an interactive moiety capable of altering the signal of the reporter moiety; and
a probe sequence which connects the first and second nucleic acid sequences. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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Specification