Interleukin-33 (IL-33) for the Diagnosis and Prognosis of Cardiovascular Disease
First Claim
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1. A method of diagnosing a cardiovascular disease in a subject, the method comprising determining a level of IL-33 in a sample from a subject, wherein the level of IL-33 in the sample is indicative of whether the subject has a cardiovascular disease.
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Abstract
The present invention includes methods for the use of interleukin-33 (IL-33) in the diagnosis of cardiovascular conditions including acute coronary syndrome (ACS), myocardial infarction, and/or heart failure, angina, cardiac hypertrophy, arteriosclerosis, myocarditis, pericarditis, endocarditis, stroke and/or pulmonary embolism and the determination of the severity of such conditions (prognosis).
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20 Claims
- 1. A method of diagnosing a cardiovascular disease in a subject, the method comprising determining a level of IL-33 in a sample from a subject, wherein the level of IL-33 in the sample is indicative of whether the subject has a cardiovascular disease.
- 2. A method of determining the severity of a cardiovascular disease in a subject, the method comprising determining a level of IL-33 in a sample from a subject, wherein the level of IL-33 in the sample is indicative of the severity of the cardiovascular disease in the subject.
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12. A method of monitoring the condition of a subject previously diagnosed with a cardiovascular condition, the method comprising:
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determining a first level of IL-33 in a sample from a subject; determining at least one subsequent level of IL-33 in a sample from the subject; and comparing the level of IL-33 in the subsequent sample to the level of IL-33 in the first sample, wherein a difference in the IL-33 level in the subsequent sample relative to the level in the first sample is correlated with a change in the patient'"'"'s condition. - View Dependent Claims (13, 14, 15, 16)
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Specification