NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS
First Claim
Patent Images
1. An construct for generating induced Pluripotent Stem (iPS) cells, comprising:
- a receptor binding domain, a translocation domain, a cargo bearing domain, and an inducer.
2 Assignments
0 Petitions
Accused Products
Abstract
A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo bearing domain to which the inducer is attached and facilitates transfer of the inducer into the cell.
46 Citations
22 Claims
-
1. An construct for generating induced Pluripotent Stem (iPS) cells, comprising:
a receptor binding domain, a translocation domain, a cargo bearing domain, and an inducer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
22. An construct for generating induced Pluripotent Stem (iPS) cells, comprising:
an atoxic clostridium toxin and an inducer, wherein said clostridium toxin further comprises a receptor binding domain and a translocation domain.
Specification