MOLECULAR INDICATOR AND PROCESS OF SYNTHESIZING

• US 20110053276A1
• Filed: 08/25/2008
• Published: 03/03/2011
• Est. Priority Date: 08/23/2007
• Status: Abandoned Application

• Current Assignee: Battelle Memorial Institute
• Original Assignee: Battelle Memorial Institute
• Inventors: Zehnder, Donald W. II, Shaw, John R.
• Application Number:
  US12/674,239
• Publication Number:
  US 20110053276A1
• Time in Patent Office: Days
• US Class Current: 436/20
• CPC Class Codes: B01J 2220/49 Materials comprising an indicator, e.g. colour indicator, pH-indicator
• CPC Class Codes: C07D 323/00 Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
• CPC Class Codes: C08G 65/331 containing oxygen cyclic ether compounds C08G65/26
• CPC Class Codes: C08G 65/333 containing nitrogen
• CPC Class Codes: C08G 65/33389 aromatic
• CPC Class Codes: C08G 65/337 containing other elements organic compounds containing halogens only as halides of a carboxyl group C08G65/332
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence

Abstract

A molecular indicator for detecting primary diamines includes an indicator structure coupled to (a) a bis-crown ether structure or (b) a structure having a bis-crown ether-like functionality. A package for detecting an analyte emitted by a packaged object includes a packaging material for the object. The package further includes a molecular indicator included with the packaging material for detecting the analyte. The molecular indicator includes an indicator structure coupled to a trapping structure for trapping the analyte. The molecular indicator is highly specific for the analyte, and the trapping of the analyte by the molecular indicator avoids reactive chemistry by-products. The molecular indicator can be synthesized by several different process schemes.

Claims

1. A molecular indicator for detecting primary diamines comprising an indicator structure coupled to (a) a bis-crown ether structure or (b) a structure having a bis-crown ether-like functionality.

2. The molecular indicator of claim 1, wherein the indicator structure comprises a colorimetric indicator.

3. The molecular indicator of claim 1, wherein the indicator structure is coupled to a bis-crown ether structure.

4. The molecular indicator of claim 1, wherein primary diamines are biogenic amines produced by meat spoilage.

5. The molecular indicator of claim 1, wherein the molecular indicator can be included with a substrate.

6. The molecular indicator of claim 5, wherein the molecular indicator can be included inside the substrate or on a surface of the substrate.

7. The molecular indicator of claim 5, wherein the substrate comprises paper, paperboard, polymer, plastic, cotton, resin, glass, fiberglass, or textile fabric.

8. The molecular indicator of claim 5, wherein the molecular indicator can be included inside a substrate in the form of a polymer matrix.

9. A package for detecting an analyte emitted by a packaged object comprising:

a packaging material for the object; and

a molecular indicator included with the packaging material for detecting the analyte, the molecular indicator comprising an indicator structure coupled to a trapping structure for trapping the analyte, the molecular indicator being highly specific for the analyte, and the trapping of the analyte by the molecular indicator avoiding reactive chemistry by-products.

10. The package of claim 9, wherein the packaged object is packaged food and the molecular indicator detects food spoilage.

11. The package of claim 10, wherein the molecular indicator detects primary diamines from food spoilage, and the molecular indicator comprises an indicator structure coupled to (a) a bis-crown ether structure or (b) a structure having a bis-crown ether-like functionality.

12. The package of claim 11, wherein the indicator structure is coupled to a bis-crown ether structure.

13. The package of claim 11, wherein the indicator structure comprises a colorimetric indicator.

14. The package of claim 9, wherein the analyte is a first analyte and the molecular indicator is a first molecular indicator, and further comprising a second molecular indicator as described in claim 9 for detecting a second analyte.

15. The package of claim 9, wherein the molecular indicator is a first molecular indicator, and further comprising a second molecular indicator as described in claim 9, the second molecular indicator cooperating with the first molecular indicator to enhance detection of the analyte.

16. The package of claim 15, wherein the first and second molecular indicators are different colorimetric indicators that cooperate to enhance visual detection of the analyte.

17. The package of claim 9 wherein the packaging material further includes an additive for enhancing the detection of the analyte.

18. A process of synthesizing a molecular indicator comprising the following scheme:

19. A process of synthesizing a molecular indicator comprising the following scheme:

20. A process of synthesizing a molecular indicator comprising the following scheme:

21. A process of synthesizing a molecular indicator comprising the following scheme: