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METHODS FOR TREATING SEPTIC SHOCK

  • US 20110053830A1
  • Filed: 09/01/2010
  • Published: 03/03/2011
  • Est. Priority Date: 08/07/2006
  • Status: Abandoned Application
First Claim
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1. A method for treating a subject with septic shock, comprisingselecting a subject with septic shock;

  • andadministering to the subject a therapeutically effective amount of a therapeutic polypeptide, wherein the therapeutic polypeptide consists of;

    (a) a first polypeptide consisting of 11 to 18 consecutive amino acids of the amino acid sequence set forth in SEQ ID NO;

    1 (A52R), or wherein the first polypeptide consists of 11 to 18 consecutive amino acids of amino acid sequence set forth as SEQ ID NO;

    1 with a single amino acid substitution thereof, wherein the first retains the ability to inhibit Toll-like receptor activity as the 11 to 18 consecutive amino acids of the amino acid sequence set forth in SEQ ID NO;

    1, and(b) a second polypeptide consisting of seven to ten consecutive arginine residues,thereby treating the septic shock in the subject.

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