METHODS TO REDUCE THE EFFECTS OF SLEEP DEPRIVATION
First Claim
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1. A method of treating at least one symptom of sleep deprivation in a subject in need thereof, comprising administering a hypocretin agonist to said subject in an amount effective to treat said at least one symptom of sleep deprivation.
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Abstract
The invention provides methods of treating symptoms of sleep deprivation using a hypocretin agonist. The invention also provides methods of treating Parkinson'"'"'s disease using a hypocretin agonist.
50 Citations
48 Claims
- 1. A method of treating at least one symptom of sleep deprivation in a subject in need thereof, comprising administering a hypocretin agonist to said subject in an amount effective to treat said at least one symptom of sleep deprivation.
- 3. (canceled)
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7. (canceled)
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13-14. -14. (canceled)
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16. (canceled)
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19-20. -20. (canceled)
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24. (canceled)
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27-41. -41. (canceled)
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42. A method of treating a symptom of Parkinson'"'"'s disease comprising administering hypocretin or a hypocretin analog to a patient having Parkinson'"'"'s disease.
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43-47. -47. (canceled)
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48. A method of determining a clinical stage of Parkinson'"'"'s disease in a patient, comprising:
determining a level of hypocretin in a body fluid of the patient, wherein loss of hypocretin is correlated with clinical stage of the disease.
Specification