AMINO ACID SEQUENCES DIRECTED AGAINST HETERODIMERIC CYTOKINES AND/OR THEIR RECEPTORS AND POLYPEPTIDES COMPRISING THE SAME
First Claim
1. Protein or polypeptide, comprising at least one amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against the p19 subunit and at least one amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against the p40 subunit, optionally linked via a suitable linker, and optionally comprising one or more further amino acid sequences, binding domains and/or binding units.
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Accused Products
Abstract
The present invention relates to amino acid sequences that are directed against (at defined herein) heterodimeric cytokines and/or their receptors, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consists of one or more such amino acid sequences ( also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as “nucleic acids of the invention” or “nucleotides sequences of the invention”); to methods for preparing such amino acid sequences and polypeptides; to hose cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that complete such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.
16 Citations
38 Claims
- 1. Protein or polypeptide, comprising at least one amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against the p19 subunit and at least one amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against the p40 subunit, optionally linked via a suitable linker, and optionally comprising one or more further amino acid sequences, binding domains and/or binding units.
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5. (canceled)
- 6. Protein or polypeptide, comprising at least one amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against a first epitope or antigenic determinant on the p19 subunit and at least one further amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against a second epitope or antigenic determinant on the p19 subunit different from the first, optionally linked via a suitable linker, and optionally comprising one or more further amino acid sequences, binding domains and/or binding units.
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8. Protein or polypeptide, comprising at least one amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against a first epitope or antigenic determinant on the p40 subunit and at least one further amino acid sequence that forms and/or essentially consist of a single (antigen) binding domain or binding unit, and/or that is capable of forming and/or of functioning as a single (antigen) binding domain or binding unit (optionally after suitable folding), and that is directed against a second epitope or antigenic determinant on the p40 subunit different from the first, optionally linked via a suitable linker, and optionally comprising one or more further amino acid sequences, binding domains and/or binding units.
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10. (canceled)
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12. (canceled)
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14. Protein or polypeptide that is directed against a heterodimeric protein, polypeptide, ligand or receptor that comprises:
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at least a first subunit; and at least a second subunit; wherein said protein or polypeptide at least comprises a first binding domain or binding unit that is directed against said first subunit and a second binding domain or binding unit that is directed against said second subunit. - View Dependent Claims (19, 21, 38)
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15. Protein or polypeptide that is directed against a first heterodimeric protein, polypeptide, ligand or receptor that comprises:
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at least a first subunit that is shared between said first heterodimeric protein, polypeptide, ligand or receptor and at least a second, different heterodimeric protein, polypeptide, ligand or receptor; and at least a second subunit that is not shared between said first heterodimeric protein, polypeptide, ligand or receptor and said second, different heterodimeric protein, polypeptide, ligand or receptor; wherein said protein or polypeptide at least comprises a first binding domain or binding unit that is directed against said first (i.e. shared) subunit and a second binding domain or binding unit that is directed against said second (i.e. not shared) subunit. - View Dependent Claims (17, 18)
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16. Protein or polypeptide that is directed against a first heterodimeric protein, polypeptide, ligand or receptor that comprises:
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at least a first subunit; and at least a second subunit; wherein said protein or polypeptide at least comprises a first binding domain or binding unit that is directed against said first subunit and a second binding domain or binding unit different from said first binding domain or binding unit that is also directed against said first subunit, but against a different epitope, antigenic determinant or binding site on said first subunit.
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20. (canceled)
- 25. Method for providing, constructing, and/or as part of (a nucleotide sequence and/or nucleic acid that encodes) a multivalent, multispecific and/or multiparatopic construct, protein and/or polypeptide that comprises a p19+ sequence (one or more) and one or more further binding domains or binding units, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the p19+ sequence.
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26. Method for providing, constructing, and/or as part of (a nucleotide sequence and/or nucleic acid that encodes) a multivalent, multispecific and/or multiparatopic construct, protein and/or polypeptide that comprises a p19−
- sequence (one or more) and one or more further binding domains or binding units, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the p19−
sequence.
- sequence (one or more) and one or more further binding domains or binding units, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the p19−
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27. Method for providing, constructing, and/or as part of (a nucleotide sequence and/or nucleic acid that encodes) a multivalent, multispecific and/or multiparatopic construct, protein and/or polypeptide that comprises a p40−
- sequence (one or more) and one or more further binding domains or binding units, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the p40−
sequence.
- sequence (one or more) and one or more further binding domains or binding units, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the p40−
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28. Method for providing, constructing, and/or as part of (a nucleotide sequence and/or nucleic acid that encodes) a multivalent, multispecific and/or multiparatopic construct, protein and/or polypeptide that comprises a p40+ sequence (one or more) and one or more further binding domains or binding units, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the p40+ sequence.
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29-32. -32. (canceled)
- 34. Method for providing, constructing, and/or as part of (a nucleotide sequence and/or nucleic acid that encodes) a multispecific construct, protein and/or polypeptide that is directed against a heterodimeric protein, polypeptide, ligand or receptor, wherein said construct, protein and/or polypeptide comprises an amino acid sequence (one or more) and at least one further binding domain or binding unit, and wherein said one or more amino acid sequences are directed against a first subunit of the heterodimeric protein, polypeptide, ligand or receptor and at least one of said further binding domains or binding units is directed against a second subunit of the heterodimeric protein, polypeptide, ligand or receptor different from the first subunit, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the amino acid sequence that comprises or essentially consists of a single binding domain or binding unit.
- 36. Method for providing, constructing, and/or as part of (a nucleotide sequence and/or nucleic acid that encodes) a biparatopic construct, protein and/or polypeptide that is directed against a heterodimeric protein, polypeptide, ligand or receptor, wherein said construct, protein and/or polypeptide comprises an amino acid sequence (one or more) and at least one further binding domain or binding unit, and wherein said one or more amino acid sequences are directed against a first subunit of the heterodimeric protein, polypeptide, ligand or receptor and at least one of said further binding domains or binding units is also directed against said first subunit, but to a different epitope or antigenic determinant on said subunit, comprising use of (a nucleotide sequence and/or nucleic acid that encodes) the amino acid sequence that comprises or essentially consists of a single binding domain or binding unit.
Specification