Nonlinear System Identification Techniques and Devices for Discovering Dynamic and Static Tissue Properties
First Claim
1. A device for measuring a mechanical property of a tissue, the device comprising:
- a probe configured to perturb the tissue with lateral movement relative to a surface of the tissue;
an actuator coupled to the probe to move the probe;
a detector configured to measure a response of the tissue to the perturbation; and
a controller coupled to the actuator and the detector, the controller driving the actuator using a stochastic sequence and determining the mechanical property of the tissue using the measured response received from the detector.
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Abstract
A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.
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Citations
58 Claims
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1. A device for measuring a mechanical property of a tissue, the device comprising:
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a probe configured to perturb the tissue with lateral movement relative to a surface of the tissue; an actuator coupled to the probe to move the probe; a detector configured to measure a response of the tissue to the perturbation; and a controller coupled to the actuator and the detector, the controller driving the actuator using a stochastic sequence and determining the mechanical property of the tissue using the measured response received from the detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of measuring a mechanical property of tissue comprising:
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placing a probe against a surface of the tissue; mechanically perturbing the tissue with lateral movement of the probe using a stochastic sequence; measuring a response of the tissue to the perturbation; and determining a mechanical property of the tissue based on the measured response to the perturbation. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of testing produce, the method comprising:
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placing a probe against a skin of a piece of produce; mechanically perturbing the piece of produce with the probe; measuring a response of the piece of produce to the perturbation; and analyzing the measured response using non-linear stochastic system identification. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method of analyzing mechanical properties of tissue comprising:
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mechanically perturbing the tissue using a stochastic input sequence; measuring a response of the tissue to the perturbation; partitioning the measured response; and generating a representation of the mechanical properties of the tissue based on the partitioned response. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51)
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52. A method of analyzing mechanical properties of tissue comprising:
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mechanically perturbing the tissue with a probe using a stochastic input sequence; measuring a response of the tissue to the perturbation; analyzing the measured response; and while perturbing, adjusting the input sequence based on the analysis. - View Dependent Claims (53, 54, 55, 56, 57, 58)
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Specification