DEVICE FOR CONSERVING, EXTEMPORANEOUSLY PREPARING, AND ADMINISTERING AN ACTIVE PRINCIPLE

• US 20110054437A1
• Filed: 04/17/2009
• Published: 03/03/2011
• Est. Priority Date: 04/17/2008
• Status: Active Grant

• Current Assignee: Philippe Perovitch, Tatiana Galperine
• Original Assignee: Philippe Perovitch, Tatiana Galperine
• Inventors: Perovitch, Philippe, Galperine, Tatiana
• Granted Patent: US 8,870,844 B2
• Time in Patent Office: Days
• US Class Current: 604/411
• CPC Class Codes: A61J 1/065 Rigid ampoules, e.g. glass ampoules
• CPC Class Codes: A61J 1/2027 having frangible parts
• CPC Class Codes: A61J 1/2086 for fluid filtration
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: B65D 51/2835 ruptured by a sharp element, e.g. a cutter or a piercer

Abstract

The invention provides a device (10) for conserving and extemporaneously preparing at least one active principle prior to administration, the device comprising: a body (12) that is constituted by at least one compartment for containing at least one volume of pharmaceutical solvent (22) that is less than 5 mL; a head (14) constituted by at least one compartment for containing at least one active principle (24), in particular a very small dose, and, in its top portion, by at least one dose-taking chamber (32) provided with a filter (40), the head (14) being capable of taking up a first position P1 for conservation, in which said head (14) is in its distal position relative to the body (12), and a second position P2 for preparation, in which said head (14) is in its proximal position relative to the body (12); at least one wall (16) separating the body (12) and the head (14); and rupture means (18) for rupturing said wall (16) so that the active principle (24) enters into contact with the solvent (22) and dissolves therein. The invention also seeks to use the device for conserving and extemporaneously preparing at least one active principle with a view to administering it.

Claims

1. A device (10) for conserving and extemporaneously preparing at least one active principle prior to administration, the device comprising:

a body (12) that is constituted by at least one compartment for containing at least one volume of pharmaceutical solvent (22) that is less than 5 mL;

a head (14) constituted by at least one compartment for containing at least one active principle (24), and, in its top portion, by at least one dose-taking chamber (32) provided with a filter (40), the head (14) being capable of taking up a first position P1 for conservation, in which said head (14) is in its distal position relative to the body (12), and a second position P2 for preparation, in which said head (14) is in its proximal position relative to the body (12);

at least one wall (16) separating the body (12) and the head (14); and

rupture means (18) for rupturing said wall (16) so that the active principle (24) enters into contact with the solvent (22) and dissolves therein.

2. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that it includes means (26) for moving the head (14) in translation, the means comprising a screw thread (30) that is carried by the body (12), and tapping (34) of complementary profile to the screw thread of the container, and that is carried by the head (14) in such a manner as to co-operate by screw-fastening.

3. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that it includes safety-locking means (28) so as to prevent any involuntary movement, in translation, of the head (14) relative to the body (12).

4. A device (10) according to claim 3, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that the locking means (28) comprise a removable ring (36) that is interposed between the head (14) in its distal position and the body (12).

5. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that the head (14) is provided with a sterile perforatable membrane (38) for protecting the dose.

6. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that the rupture means (18) for rupturing the wall (16) are cutter means that are capable of tearing said wall (16) when the head (14) is in its proximal position.

7. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that it includes a protective cap (42) that is held on the head (14) by a safety tab (44).

8. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that it includes a grip paddle (46) that is disposed at the bottom portion of the body (12), so as to make a good two-digit pinch grip possible.

9. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that it includes grip means (48) that are disposed in the top portion of the body (12).

10. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that, on its peripheral outside surface, the head (14) includes grip means (50).

11. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that the head (14) includes at least two compartments (52-1, 52-2) for containing at least an active principle, an excipient, and/or a solvent, said compartments being separated by at least one wall (54), and at least one of the compartments (52-1, 52-2) containing an active principle.

12. A device (10) according to any preceding claim, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that the body (12) includes at least two compartments (52-3, 52-4) for containing at least an active principle and/or an excipient and/or a solvent, said compartments being separated by at least one wall (16-2), and at least one of the compartments (52-3, 52-4) containing a solvent.

13. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that the body (12) and the head (14) and/or each compartment of the device are separated by at least one wall and by at least one additional membrane.

14. A device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle prior to administration, the device being characterized in that said active principle forms part of the family of beta-lactamides, preferably cefuroxime or cefazolin.

15. Use of a device (10) according to claim 1, for conserving and extemporaneously preparing at least one active principle with a view to administering it by injecting intravenously, intramuscularly, subcutaneously, or into certain organ structures, tissues, or defined cavities.

16. Use of a device (10) according to claim 1, for conserving and extemporaneously preparing at least one antibiotic active principle that forms part of the family of beta-lactamines, with a view to administering it intracamerally so as to prevent post-phacocystectomy infections.

17. Use of a device (10) according to claim 1, for conserving at least one anti-angiogenic active principle and at least one antibiotic active principle and for combining them extemporaneously with a view to administering them by intravitreal injection.

18. Use of a device (10) according to claim 1, for conserving and extemporaneously preparing at least one labile active principle of peptide nature or resulting from biotechnology with a view to administering it by injecting intravenously, intramuscularly, subcutaneously, or into certain organ structures, tissues, or defined cavities.