PROPHYLACTIC AND THERAPEUTIC INFLUENZA VACCINES, ANTIGENS, COMPOSITIONS AND METHODS
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Abstract
The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by influenza virus. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and subunit vaccine compositions. In some embodiments, influenza antigens include hemagglutinin polypeptides neuraminidase polypeptides, and/or combinations thereof.
97 Citations
67 Claims
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1-47. -47. (canceled)
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48. An immunogenic composition comprising:
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An influenza polypeptide antigen; and a pharmaceutically acceptable excipient; wherein the composition elicits an immune response upon administration to a subject. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. A method for producing an influenza antigen polypeptide comprising:
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a. administering a nucleic acid construct encoding an influenza antigen polypeptide into a plant cell; and b. incubating the plant cell under conditions favorable for expression of the influenza antigen polypeptide; thereby producing the influenza antigen polypeptide. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66)
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67. An isolated nucleic acid construct comprising nucleic acid sequence encoding an influenza antigen polypeptide, wherein the influenza antigen polypeptide comprises a sequence as set forth in any one of SEQ ID NOs:
- 1-43, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 and 109.
Specification