MODIFICATION OF SURFACES WITH NANOPARTICLES

• US 20110059264A1
• Filed: 07/27/2010
• Published: 03/10/2011
• Est. Priority Date: 07/27/2009
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Turro, Nicholas J., Park, Ellane J., Koberstein, Jeffrey T.
• Granted Patent: US 9,296,870 B2
• Time in Patent Office: Days
• US Class Current: 427/510
• CPC Class Codes: C08J 2325/06 Polystyrene
• CPC Class Codes: C08J 7/18 using wave energy or particle radiation
• CPC Class Codes: C09D 1/00 Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
• CPC Class Codes: C09D 7/62 modified by treatment with other compounds
• CPC Class Codes: C09D 7/67 Particle size smaller than 100 nm

Abstract

Methods for functionalizing a surface of a substrate with nanoparticles are described. In certain embodiments, the method can include attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group; depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive nanoparticles with radiation to react the photoactive group with the reactive group and to functionalize the surface of the substrate with nanoparticles. In certain embodiments, the method can include attaching a plurality of photoactive linker to a surface of a substrate to obtain a photoactive surface, wherein each photoactive linker comprises a photoactive group and a binding group that attaches to the surface of the substrate; depositing nanoparticles to the photoactive surface, wherein the nanoparticles comprise reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive surface with radiation to react the photoactive group with the reactive group to functionalize the surface of the substrate with nanoparticles.

Claims

1. A method for functionalizing a surface of a substrate with nanoparticles, the method comprising:

attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group;

depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises hydrogen-containing reactive groups that are capable of reacting with the photoactive groups; and

irradiating the photoactive nanoparticles with radiation to react the photoactive group with the hydrogen-containing reactive group and to functionalize the surface of the substrate with nanoparticles.

2. The method of claim 1, further comprising:

applying a mask having a pre-selected pattern to the surface of the substrate prior to said irradiating.

3. The method of claim 1, wherein the nanoparticles are selected from the group consisting of metal oxide nanoparticles, gold nanoparticles, quantum dots, magnetic nanoparticles, photonic nanoparticles, and drug delivery nanoparticles.

4. The method of claim 1, wherein the nanoparticles have at least one dimension of about 10 to about 100 nm.

5. The method of claim 1, wherein the photoactive linker further comprises a spacer.

6. The method of claim 1, wherein the photoactive groups are selected from the group consisting of phthalimide, benzophenone, phenyl azide, xanthone, thioxanthone, sulfonyl azides, phenyl diazirine, and combinations thereof.

7. The method of claim 1, wherein the substrate comprises an organic material comprising C—

H bonds, N—

H bonds, or S—

H bonds.

8. The method of claim 1, wherein said photoactive linker comprises C—

H bonds, N—

H bonds, or S—

H bonds.

9. The method of claim 8, wherein said irradiating reacts said photoactive groups to the photoactive linker through the C—

H bonds, N—

H bonds, or S—

H bonds.

10. The method of claim 1, further comprising depositing additional photoactive nanoparticles after said depositing the photoactive nanoparticles to the surface of the substrate.

11. A method for functionalizing a surface of a substrate with nanoparticles, the method comprising:

attaching a plurality of photoactive linker to a surface of a substrate to obtain a photoactive surface, wherein each photoactive linker comprises a photoactive group and a binding group that attaches to the surface of the substrate;

depositing nanoparticles to the photoactive surface, wherein the nanoparticles comprise hydrogen-containing reactive groups that are capable of reacting with the photoactive groups; and

irradiating the photoactive surface to react the photoactive group with the hydrogen-containing reactive group to functionalize the surface of the substrate with nanoparticles.

12. The method of claim 11, further comprising:

applying a mask having a pre-selected pattern to the surface of the substrate prior to said irradiating.

13. The method of claim 11, wherein the nanoparticles are selected from the group consisting of metal oxide nanoparticles, gold nanoparticles, quantum dots, magnetic nanoparticles, photonic nanoparticles, and drug delivery nanoparticles.

14. The method of claim 11, wherein the nanoparticles have at least one dimension of about 10 to about 100 nm.

15. The method of claim 11, wherein the photoactive linker further comprises a spacer.

16. The method of claim 11, wherein the photoactive groups are selected from the group consisting of phthalimide, benzophenone, phenyl azide, xanthone, thioxanthone, sulfonyl azides, phenyl diazirine, and combinations thereof.

17. The method of claim 11, wherein the substrate comprises an organic material comprising C—

H bonds, N—

H bonds, or S—

H bonds.

18. The method of claim 11, further comprising:

attaching a plurality of a second photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each of the second photoactive linker comprises a binding group that attaches to the nanoparticles and a second photoactive group; and

depositing the photoactive nanoparticles to the substrate, wherein said second photoactive linker is same or different from said photoactive linker attached to the surface.

19. The method of claim 18, wherein said second photoactive linker comprises C—

H bonds, N—

H bonds, or S—

H bonds.

20. The method of claim 18, wherein said irradiating reacts said second photoactive groups to the second photoactive linker through the C—

H bonds, N—

H bonds, or S—

H bonds.