LIPID ENCAPSULATING INTERFERING RNA
First Claim
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1. An nucleic acid-lipid particle, said nucleic acid-lipid particle comprising:
- (a) an interfering RNA;
(b) a cationic lipid of Formula I and having the following structure;
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Abstract
The present invention provides lipid-based formulations for delivering, e.g., introducing, nucleic acid-lipid particles comprising an interference RNA molecule to a cell, and assays for optimizing the delivery efficiency of such lipid-based formulations.
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Citations
37 Claims
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1. An nucleic acid-lipid particle, said nucleic acid-lipid particle comprising:
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(a) an interfering RNA; (b) a cationic lipid of Formula I and having the following structure; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of introducing an interfering RNA into a cell, said method comprising contacting said cell with a nucleic acid-lipid particle comprising
(a) said interfering RNA; (b) a cationic lipid of Formula I and having the following structure; - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for in vivo delivery of interfering RNA, said method comprising administering to a mammalian subject a nucleic acid-lipid particle comprising:
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(a) said interfering RNA; (b) a cationic lipid of Formula I and having the following structure; - View Dependent Claims (34, 35, 36, 37)
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Specification