TWO-CHAMBER INJECTION DEVICE HAVING GAS-PERMEABLE MEMBRANE

• US 20110060274A1
• Filed: 06/15/2010
• Published: 03/10/2011
• Est. Priority Date: 12/19/2007
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: KUHN, Bernd
• Granted Patent: US 8,376,987 B2
• Time in Patent Office: Days
• US Class Current: 604/82
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2205/7509 for virus
• CPC Class Codes: A61M 2205/7536 allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/3134 characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
• CPC Class Codes: A61M 5/385 using hydrophobic filters

Abstract

The invention relates to a two-chamber syringe device comprising a cylinder element (2), a closure element (6), two plungers (3) and (4) and optionally an intermediate plunger (3a), wherein one or more fluid-tight, gas-permeable membranes (8) and optionally valve membranes (15) are arranged in the wall of the cylinder element (2) or in the closure element (6), allowing gas in the chambers to escape from the cylinder element (2) when the plungers (3), (3a) and (4) are displaced in the distal direction.

Claims

1. A two-chamber syringe device comprising

a) a cylinder element (2) with a distal outlet opening (5a), a proximal opening (5b) and one or more transfer channels (9),

b) a closure element (6) of the distal outlet opening (5a) comprising a sealing disk (11) and a fixing sleeve (12), and

c) a distal plunger (3) and a proximal plunger (4), which can be introduced into the cylinder element (2),

a chamber A being formed between the closure element (6) and the distal plunger (3) inside the cylinder element (2),

wherein one or more fluid-tight, gas-permeable membranes (8) are arranged in the wall of the cylinder element (2) or in the closure element (6).

2. The two-chamber syringe device as claimed in claim 1, wherein the cylinder element (2) is formed as one part and comprises the cylinder (2a).

3. The two-chamber syringe device as claimed in claim 1, wherein the cylinder element (2) is formed as two parts and comprises the distal part-cylinder (2b) and the proximal part-cylinder (2c).

4. The two-chamber syringe device as claimed in claim 3, wherein, between plungers (3) and (4), a further plunger (3a) is arranged at the distal end of the proximal part-cylinder (2c).

5. The two-chamber syringe device as claimed in claim 1, the closure element (6) including an element for fastening a needle.

6. The two-chamber syringe device as claimed in claim 1, the closure element (6) including a spacer ring (10), which is positioned between the sealing disk (11) and the cylinder element (2), and optionally includes a sealing ring (21) between the spacer ring (10) and the cylinder element (2).

7. The two-chamber syringe device as claimed in claim 1, the two-chamber syringe device including a protective cap (14) for fitting onto the distal end of the cylinder element (2) and/or the distal end of the closure element (6).

8. The two-chamber syringe device as claimed in claim 1, wherein the fluid-tight, gas-permeable membrane (8) is arranged in the wall of the cylinder element (2) at the distal end of the cylinder element (2) in the region of the chamber A.

9. The two-chamber syringe device as claimed in claim 1, wherein the fluid-type, gas-permeable membrane (8) is arranged in the closure element (6).

10. The two-chamber syringe device as claimed in claim 9, wherein the sealing disk (11) represents the fluid-type, gas-permeable membrane (8).

11. The two-chamber syringe device as claimed in claim 1, wherein a valve element (15) is arranged over the fluid-tight, gas-permeable membrane (8).

12. The two-chamber syringe device as claimed in claim 1, wherein the fluid-tight, gas-permeable membrane (8) is a sterile filter membrane.

13. The two-chamber syringe device as claimed in claim 12, the sterile filter membrane having a pore size of less than or equal to 0.2 μ

m.

14. The two-chamber syringe device as claimed in claim 1, wherein the distal chamber A contains a solid component and the proximal chamber B contains a liquid component.

15. The two-chamber syringe device as claimed in claim 1, wherein both chambers A and B contain a liquid component.

16. The two-chamber syringe device as claimed in claim 1, wherein the syringe device is formed as a carpule.

17. The two-chamber syringe device as claimed in claim 1, wherein the syringe device is formed as a disposable syringe, a needle intended for piercing the sealing disk (11) being fastened to the distal end of the cylinder element (2), and the syringe device including a device for moving the plunger (4) in the distal direction.

18. An outer packaging for a two-chamber syringe device as claimed in claim 1, wherein the outer packaging is produced from a gas-tight sheet material.

19. The outer packaging as claimed in claim 18, wherein the outer packaging material is aluminum foil, plastic-laminated aluminum foil or aluminum-coated plastic film.

20. An applicator including a two-chamber syringe device as claimed in claim 1, a needle for attaching to the distal end of the cylinder element (2) and optionally one or more disinfection pads.