Reduced Volume Formulation of Glatiramer Acetate and Methods of Administration
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Accused Products
Abstract
A method for reducing frequency of relapses in a human patient afflicted with relapsing-remitting multiple sclerosis (RRMS) comprising administering to the patient 0.5 ml of an aqueous pharmaceutical solution of 20 mg glatiramer acetate and 20 mg mannitol.
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Citations
41 Claims
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1-20. -20. (canceled)
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21. An injection assisting device comprising:
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a first outer shell having a first internal cavity with first and second oppositely arranged openings and a second outer shell movably and removably connectable to the first outer shell, the second outer shell having a second internal cavity with at least a first opening oriented towards the second opening of the first outer shell; a button configured to initiate an injection; an injection locking member configured to prevent the initiation of an injection in the absence of a predetermined compressive force between the second assembly and the first assembly; an injection energy storing member configured to absorb and retain a predetermined amount of injection energy applied to a syringe located within at least one of the first and second cavities during an injection; an injection actuator configured, upon the initiation of an injection, to apply the injection energy to the syringe so as to displace a predetermined amount of matter from within the syringe; an injection completion indicator inside an indicator window, configured to indicate to a user when the predetermined amount of matter has been displaced from within the syringe; and an injection lock indicator outside of the indicator window, configured to indicate to a user whether the injection locking member is in a locked state, and configured to substantially contrast with a color of both of the first outer shell and the second outer shell, and configured to be substantially shielded from a view of a user in the presence of the predetermined amount of compression force between the second outer shell and the first outer shell. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification