Method and System for Computational Modeling of the Aorta and Heart
First Claim
1. A method for multi-component heart modeling and cardiac disease decision support, comprising:
- generating a multi-component patient specific 4D geometric model of the heart and aorta estimated from a sequence of volumetric cardiac imaging data of a patient generated using at least one medical imaging modality;
generating a patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model; and
estimating patient specific material properties of an aortic wall using the 4D geometrical model and the 4D computational model.
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Abstract
A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient'"'"'s cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.
125 Citations
28 Claims
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1. A method for multi-component heart modeling and cardiac disease decision support, comprising:
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generating a multi-component patient specific 4D geometric model of the heart and aorta estimated from a sequence of volumetric cardiac imaging data of a patient generated using at least one medical imaging modality; generating a patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model; and estimating patient specific material properties of an aortic wall using the 4D geometrical model and the 4D computational model. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 27, 28)
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13. An apparatus for multi-component heart modeling and cardiac disease decision support, comprising:
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means for generating a multi-component patient specific 4D geometric model of the heart and aorta estimated from a sequence of volumetric cardiac imaging data of a patient generated using at least one medical imaging modality; means for generating a patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model; and means for estimating patient specific material properties of an aortic wall using the 4D geometrical model and the 4D computational model. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A non-transitory computer readable medium encoded with computer executable instructions for multi-component heart modeling and cardiac disease decision support, the computer executable instructions defining steps comprising:
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generating a multi-component patient specific 4D geometric model of the heart and aorta estimated from a sequence of volumetric cardiac imaging data of a patient generated using at least one medical imaging modality; generating a patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model; and estimating patient specific material properties of an aortic wall using the 4D geometrical model and the 4D computational model. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification