OPTICALLY INTEGRATED BIOSENSOR BASED ON OPTICALLY DETECTED MAGNETIC RESONANCE
First Claim
1. An optically integrated magnetic biosensor based on optically detected magnetic resonance (ODMR) comprises:
- an ODMR center;
a fluidics layer configured to contain a solution comprising analytes, the fluidics layer being disposed over the ODMR center;
a light source configured to generate incident light which excites electrons within the ODMR center from a ground state to an excited state; and
a radio frequency (RF) antenna configured to generate an RF field incident on the ODMR center, the RF antenna being further configured to generate the RF field with frequencies which correspond to ground state transitions in the ODMR center;
in which the ODMR center produces emitted light when illuminated by the incident light, characteristics of the emitted light being influenced by the RF field and magnetic nanoparticles attached to the analytes.
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Accused Products
Abstract
An optically integrated magnetic biosensor includes an optically detected magnetic resonance (ODMR) center and a fluidics layer configured to contain a solution comprising analytes, the fluidics layer being disposed over the ODMR center. A light source which generates incident light excites electrons within the ODMR center from a ground state to an excited state and a radio frequency (RF) antenna generates an RF field incident with frequencies which correspond to ground state transitions in the ODMR center. The ODMR center produces emitted light when illuminated by the incident light. The characteristics of the emitted light are influenced by the RF field and magnetic nanoparticles attached to the analytes. A method for detecting analytes using optically detected magnetic resonance is also provided.
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Citations
20 Claims
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1. An optically integrated magnetic biosensor based on optically detected magnetic resonance (ODMR) comprises:
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an ODMR center; a fluidics layer configured to contain a solution comprising analytes, the fluidics layer being disposed over the ODMR center; a light source configured to generate incident light which excites electrons within the ODMR center from a ground state to an excited state; and a radio frequency (RF) antenna configured to generate an RF field incident on the ODMR center, the RF antenna being further configured to generate the RF field with frequencies which correspond to ground state transitions in the ODMR center; in which the ODMR center produces emitted light when illuminated by the incident light, characteristics of the emitted light being influenced by the RF field and magnetic nanoparticles attached to the analytes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for detecting analytes comprises:
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depositing a sample over a functionalized array, the functionalized array being formed on a surface containing ODMR centers, analytes within the sample selectively binding to portions of the functionalized array; attaching readout molecules to analytes bound to the functionalized array, the readout molecules being tagged with magnetic nanoparticles; exciting the ODMR centers with incident light and an RF field; and detecting the presence of analytes bound to the functionalized array by analyzing light emitted by the ODMR centers. - View Dependent Claims (19, 20)
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Specification