MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY
First Claim
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1. A method for inhibiting the development of a tumor resulting from cellular therapy in a subject receiving a cellular therapy, comprising:
- (a) administering a cellular therapy composition to a subject; and
(b) systemically administering an oncolytic virus to the subject, wherein the oncolytic virus is administered in an amount sufficient to treat or prevent formation of tumors from contaminating tumor cells in the cellular therapy composition.
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Abstract
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by administration of cellular therapies, such as stem cell therapies. The methods also include contacting cellular compositions with oncolytic viruses for the removal of neoplastic cells prior to administration of the cellular composition for therapy. Diagnostic methods for monitoring treatment also are provided.
160 Citations
51 Claims
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1. A method for inhibiting the development of a tumor resulting from cellular therapy in a subject receiving a cellular therapy, comprising:
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(a) administering a cellular therapy composition to a subject; and (b) systemically administering an oncolytic virus to the subject, wherein the oncolytic virus is administered in an amount sufficient to treat or prevent formation of tumors from contaminating tumor cells in the cellular therapy composition. - View Dependent Claims (2, 7, 8, 9, 12, 13, 14, 24, 25, 36, 37, 38, 39, 40, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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26-35. -35. (canceled)
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41. (canceled)
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51-76. -76. (canceled)
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