Nanostructure-Enhanced Platelet Binding and Hemostatic Structures
First Claim
1. A platelet binding structure, comprising:
- a base structure that includes a first material; and
a plurality of inorganic nanostructures incorporated with the base structure;
wherein the nanostructures are configured to induce platelet binding when the platelet binding structure is contacted with platelets.
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Accused Products
Abstract
Methods, systems, and apparatuses for nanomaterial-enhanced platelet binding and hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce platelet binding, including platelet binding and the coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. Example embodiments include platelet binding devices, hemostatic bandages, hemostatic plugs, and hemostatic formulations. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers, silicon nanofibers, silicon dioxide nanofibers, and/or glass beads into a highly absorbent, gelling scaffold. The hemostatic materials and structures may be resorbable.
148 Citations
38 Claims
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1. A platelet binding structure, comprising:
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a base structure that includes a first material; and a plurality of inorganic nanostructures incorporated with the base structure; wherein the nanostructures are configured to induce platelet binding when the platelet binding structure is contacted with platelets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of inducing platelet adhesion, comprising:
contacting a plurality of inorganic nanostructures incorporated within a base structure with a population of platelets. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A hemostatic structure, comprising:
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a base structure that includes a first material capable of creating a gel when contacted with blood; and a plurality of hemostatic inorganic nanoparticles incorporated with the base structure; wherein the hemostatic nanoparticles are configured to induce hemostasis when the hemostatic structure is contacted with blood. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for forming a hemostatic structure, comprising:
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providing a base structure that includes a first material capable of creating a gel when contacted with blood; and coating the base structure with a plurality of hemostatic inorganic nanoparticles such that the nanoparticles are configured to induce hemostasis when the hemostatic structure is contacted with blood. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
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Specification