ANTI-INFECTIVE LUBRICANT FOR MEDICAL DEVICES AND METHODS FOR PREPARING THE SAME

• US 20110065798A1
• Filed: 09/17/2009
• Published: 03/17/2011
• Est. Priority Date: 09/17/2009
• Status: Abandoned Application

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Khan, Mohammad A., Hoang, Minh Quang
• Application Number:
  US12/561,863
• Publication Number:
  US 20110065798A1
• Time in Patent Office: Days
• US Class Current: 514/574
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/208 Quaternary ammonium compounds
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/452 Lubricants
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/06 Coatings containing a mixture of two or more compounds
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

A lubricious antiseptic coating material containing various solvents to achieve mutual miscibility and provide a generally homogenous product. A coating material is provided having an antipathogenic agent and a solvent for dissolving the same. The coating further includes a lubricious agent and a solvent for dissolving the same. Thus, the coating material contains antiseptic and lubricious properties suitable for application to a desired surface to kill or inhibit the growth of pathogens known to cause catheter related bloodstream infections.

Claims

1. An antimicrobial composition, comprising:

an antipathogenic agent;

a first solvent capable of dissolving the antipathogenic agent, the solvent being selected from a group consisting of water, a C1 alcohol and a C2 alcohol;

a lubricious agent; and

a second solvent capable of dissolving the lubricious agent, wherein the first solvent and the second solvent are mutually miscible.

2. The composition of claim 1, wherein the lubricious agent is a silicone oil.

3. The composition of claim 1, wherein the second solvent is at least one of a hydrocarbon, a ketone, a halogenated hydrocarbon, and an alcohol having at least 3 carbon atoms.

4. The composition of claim 1, wherein the second solvent is a polyethoxylated surfactant.

5. The composition of claim 1, wherein the antipathogenic agent is at least one of chlorhexidine diacetate, chlorhexidine gluconate, triclosan, benzalkonium chloride, and para-chloro-meta-xylenol (PCMX).

6. The composition of claim 2, wherein the silicone oil is at least one of dimethylsiloxane and trifluoropropylmethylsiloxane.

7. The composition of claim 3, wherein the second solvent comprises two or more hydrocarbons, ketones, halogenated hydrocarbons, alcohols having at least three carbon atoms, and combinations thereof.

8. A method for manufacturing an antimicrobial composition, the method comprising:

selecting an antipathogenic agent;

selecting a first solvent capable of dissolving the antipathogenic agent, the solvent being selected from a group consisting of water, a C1 alcohol and a C2 alcohol;

dissolving the antipathogenic agent in the first solvent to provide a first miscible solution;

selecting a lubricious agent;

selecting a second solvent capable of dissolving the lubricious agent;

dissolving the lubricous agent in the second solvent to provide a second miscible solution; and

homogeneously mixing the first and second miscible solutions.

9. The method of claim 8, wherein the lubricious agent is a silicone oil.

10. The method of claim 8, wherein the second solvent is at least one of a hydrocarbon, a ketone, a halogenated hydrocarbon, and an alcohol having at least 3 carbon atoms.

11. The method of claim 8, wherein the second solvent is a polyethoxylated surfactant.

12. The method of claim 8, wherein the antipathogenic agent is at least one of chlorhexidine diacetate, chlorhexidine gluconate, triclosan, benzalkonium chloride, and para-chloro-meta-xylenol (PCMX).

13. The method of claim 9, wherein the silicone oil is at least one of dimethylsiloxane and trifluoropropylmethylsiloxane.

14. The method of claim 10, wherein the second solvent comprises two or more hydrocarbons, ketones, halogenated hydrocarbons, alcohols having at least three carbon atoms, and combinations thereof.

15. An intravascular system for preventing catheter-related bloodstream infections, the system comprising:

a vascular access device having an external surface; and

an antiseptic coating applied to the external surface, the antiseptic coating including;

an antipathogenic agent;

a first solvent capable of dissolving the antipathogenic agent, the solvent being selected from a group consisting of water, a C1 alcohol and a C2 alcohol;

a lubricious agent; and

a second solvent capable of dissolving the lubricous agent, wherein the first solvent and the second solvent are mutually miscible.

16. The system of claim 15, wherein the lubricous agent is a silicone oil.

17. The system of claim 15, wherein the vascular access device further comprises a syringe.

18. The system of claim 15, wherein the second solvent is at least one of a hydrocarbon, a ketone, a halogenated hydrocarbon, and an alcohol having at least 3 carbon atoms.

19. The system of claim 15, wherein the second solvent is a polyethoxylated surfactant.

20. The system of claim 16, wherein the silicone oil is at least one of dimethylsiloxane and trifluoropropylmethylsiloxane