Biosensor Membranes Composed Of Polymers Containing Heterocyclic Nitrogens

• US 20110066019A1
• Filed: 11/18/2010
• Published: 03/17/2011
• Est. Priority Date: 05/15/2001
• Status: Abandoned Application

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Cho, Hyun, Mao, Fei
• Application Number:
  US12/949,755
• Publication Number:
  US 20110066019A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.

Claims

1. (canceled)

2. A membrane for use in an analyte sensor, comprising:

a silicone polymer; and

a poly(ethylene oxide) or poly(propylene oxide), wherein the membrane is adapted to permit diffusion of both the analyte and oxygen therethrough.

3. The membrane of claim 2, wherein the membrane comprises hydroxyl substituents.

4. The membrane of claim 2, wherein the analyte is glucose.

5. An implantable analyte sensor, comprising:

an enzyme layer comprising an enzyme;

a bioprotective layer positioned between the enzyme layer and tissue adjacent to the sensor when implanted, wherein the bioprotective layer comprises a silicone polymer and a poly(ethylene oxide) or poly(propylene oxide).

6. The sensor of claim 5, wherein the membrane comprises hydroxyl substituents.

7. The sensor of claim 5, wherein the analyte is glucose.

8. The sensor of claim 5, wherein at least a portion of the membrane is cross linked.

9. A membrane for use in an analyte sensor, comprising:

a silicone polymer; and

a poly(ethylene oxide) or poly(propylene oxide), wherein the membrane is adapted to permit diffusion of both the analyte and oxygen therethrough,

wherein at least a portion of the membrane is cross linked.

10. The membrane of claim 9, wherein the membrane comprises hydroxyl substituents.

11. The membrane of claim 9, wherein the analyte is glucose.

12. An implantable analyte sensor, comprising:

an enzyme layer comprising an enzyme;

a bioprotective layer positioned between the enzyme layer and tissue adjacent to the sensor when implanted, wherein the bioprotective layer comprises a silicone polymer and a poly(ethylene oxide) or poly(propylene oxide); and

an electroactive surface configured to measure the analyte or a product of a reaction of the enzyme with the analyte.

13. The sensor of claim 12, wherein the membrane comprises hydroxyl substituents.

14. The sensor of claim 12, wherein the analyte is glucose.

15. The sensor of claim 12, wherein at least a portion of the membrane is cross linked.