METHOD AND ELECTRONIC MEDICAL DEVICE FOR SIMULTANEOUSLY MEASURING AN IMPEDANCE AND A BIOPOTENTIAL SIGNAL

• US 20110066054A1
• Filed: 09/14/2010
• Published: 03/17/2011
• Est. Priority Date: 09/14/2009
• Status: Active Grant

• Current Assignee: IMEC International
• Original Assignee: IMEC International
• Inventors: Kim, Sunyoung, Yazicioglu, Refet Firat
• Granted Patent: US 8,454,505 B2
• Time in Patent Office: Days
• US Class Current: 600/509
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: G01R 19/2509 Details concerning sampling, digitizing or waveform capturing

Abstract

A method and device is disclosed for continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject'"'"'s skin. In one aspect, the method includes attaching input and output electrodes to the biological subject'"'"'s skin and applying a predetermined alternating current having a first frequency to the output electrodes for creating an alternating voltage signal over the input electrodes. The first frequency is above a predetermined minimum frequency. The method also includes measuring an input signal from the input electrodes which includes a biopotential signal and the alternating voltage signal. The method also includes extracting from the input signal the biopotential signal and the alternating voltage signal, and determining the impedance signal from the alternating voltage signal. The alternating voltage signal is extracted by amplifying and demodulating the input signal using a control signal having a frequency equal to the first frequency.

Claims

1. A method of continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject'"'"'s skin, the method comprising:

attaching input and output electrodes to the biological subject'"'"'s skin;

applying a predetermined alternating current having a first frequency to the output electrodes for creating an alternating voltage signal over the input electrodes, the first frequency being at least a predetermined minimum frequency;

measuring an input signal from the input electrodes, the input signal comprising a biopotential signal and the alternating voltage signal;

extracting from the input signal the biopotential signal;

extracting from the input signal the alternating voltage signal by amplifying and demodulating the input signal using a control signal having a frequency equal to the first frequency; and

determining the impedance signal from the alternating voltage signal.

2. The method according to claim 1, wherein the process of extracting the alternating voltage signal comprises extracting in parallel a first and a second baseband voltage signal representative of real and imaginary components of the impedance signal.

3. The method according to claim 2, wherein the first and second baseband voltage signals are obtained by demodulating the input signal using two control signals having a frequency equal to the first frequency but 90°

phase shifted with respect to each other.

4. The method according to claim 1, wherein the predetermined alternating current is generated by chopper modulating a predetermined DC current at the first frequency and the demodulation of the input signal is performed by a chopper demodulation at the first frequency.

5. The method according to claim 1, wherein the biopotential signal is extracted from the input signal by subsequent chopper modulation, amplification and chopper demodulation of the input signal at the first frequency.

6. The method according to claim 1, wherein the biopotential signal is an ECG or an EEG signal.

7. The method according to claim 1, wherein the process of applying the alternating current and the process of measuring the input signal occur through a single set of input/output electrodes.

8. The method according to claim 1, wherein the predetermined minimum frequency is selected for achieving spectral separation of the biopotential and impedance signals.

9. The method according to claim 1, wherein the predetermined minimum frequency is at least twice an expected maximum frequency of the biopotential signal.

10. The method according to claim 1, further comprising using the impedance signal to remove motion artifacts from the biopotential signal.

11. An electronic medical device for continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject'"'"'s skin, the device comprising:

input and output electrodes provided for being attached to the biological subject'"'"'s skin and connected to input and output terminals of the device;

a current source connected to the output terminals configured to generate a predetermined alternating current having a first frequency above a predetermined minimum frequency, the predetermined alternating current being applied to the output electrodes for creating an alternating voltage signal over the input electrodes;

an impedance signal extraction module connected to the input terminals and configured to extract the alternating voltage signal from an input signal which is measured on the input electrodes and to determine the impedance signal from the alternating voltage signal, the impedance signal extraction module comprising a first amplifier connected to the input terminals and configured to amplify the input signal and a demodulation module connected to the first amplifier and configured to demodulate the input signal using a control signal having a frequency equal to the first frequency; and

a biopotential signal extraction module connected to the input terminals and configured to extract the biopotential signal from the input signal.

12. The device according to claim 11, wherein the demodulation module comprises first and second demodulation modules using two control signals having a frequency equal to the first frequency but 90°

phase shifted with respect to each other, the first and second demodulation modules being configured to extract in parallel a first and a second baseband voltage signal representative of real and imaginary components of the impedance signal.

13. The device according to claim 12, wherein the current source comprises a DC current generator and a first chopper modulator configured to generate the predetermined alternating current, and the first and second demodulation modules are chopper demodulators.

14. The device according to claim 11, wherein the biopotential signal extraction module comprises in sequence a second chopper modulator, a second amplifier, and a third chopper demodulator, the second modulator and the third demodulator being controlled by a clock signal having a second frequency, wherein the second frequency is the same as the first frequency.

15. The device according to claim 11, wherein input and output electrodes are formed by a single set of input/output electrodes connected to a single set of input/output terminals.

16. The device according to claim 11, wherein the current source has a polarity adjustment module configured to adjust the polarity of the modulated current for measuring either a total impedance or an impedance difference.

17. Use of the device according to claim 11 for measuring an ECG or an EEG signal, wherein the impedance signal is used to remove motion artifacts from the biopotential signal.

18. A device for continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject'"'"'s skin, the device comprising:

means for attaching input and output electrodes to the biological subject'"'"'s skin;

means for applying a predetermined alternating current having a first frequency to the output electrodes for creating an alternating voltage signal over the input electrodes, the first frequency being at least a predetermined minimum frequency;

means for measuring an input signal from the input electrodes, the input signal comprising a biopotential signal and the alternating voltage signal;

means for extracting from the input signal the biopotential signal;

means for extracting from the input signal the alternating voltage signal by amplifying and demodulating the input signal using a control signal having a frequency equal to the first frequency; and

means for determining the impedance signal from the alternating voltage signal.