MEDICAL DEVICE WITH ANTIMICROBIAL LAYER

• US 20110067703A1
• Filed: 12/01/2010
• Published: 03/24/2011
• Est. Priority Date: 04/29/2003
• Status: Abandoned Application

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Mallinckrodt Incorporated (Mallinckrodt plc)
• Inventors: Martens, Paul W., Virag, Robert, Potter, Adin M., Nieto, Robert L.
• Application Number:
  US12/958,091
• Publication Number:
  US 20110067703A1
• Time in Patent Office: Days
• US Class Current: 128/207.14
• CPC Class Codes: A61F 2002/046 Tracheae
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0443 Special cuff-wall materials A61M16/0481, A61M16/0422 take precedence
• CPC Class Codes: A61M 39/162 with antiseptic agent incorporated within the connector

Abstract

A medical device includes a conduit for a fluid. The conduit has a wall formed of a hydrophobic polymer with a hydrophilic polymer layer extruded over it, and an antimicrobial substantially dispersed within the hydrophilic polymer. The antimicrobial compound may be a predetermined amount of phosphorus-based glass having a predetermined quantity of a metal such as silver substantially dispersed therein. The medical device may be an endotracheal tube made by providing a hydrophobic polymer, a hydrophilic polymer and an antimicrobial compound, forming the hydrophobic polymer, the hydrophilic polymer and the antimicrobial compound into a conduit, and forming a cuff on an end of the conduit.

Claims

1. A tracheal tube comprising:

a conduit and a cuff extruded from a hydrophobic polymer, the cuff positioned on the conduit,

an outer layer extruded on an outer surface of the conduit and the cuff, the outer layer comprising a first formulation of an antimicrobial layer comprising a hydrophilic polymer and a water-soluble glass, wherein the water-soluble glass has a quantity of metal substantially dispersed therein, and

an inner layer extruded on an inner surface of the conduit, the inner layer . comprising a second formulation of an antimicrobial layer comprising a hydrophilic polymer and a water-soluble glass, wherein the water-soluble glass has a quantity of metal substantially dispersed therein.

2. The tracheal tube, as set forth in claim 1, wherein the metal of the first formulation comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.

3. The tracheal tube, as set forth in claim 1, wherein the metal of the second formulation comprises copper, gold, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or a combination thereof.

4. The tracheal tube, as set forth in claim 1, wherein the water-soluble glass of the first formulation comprises a phosphorous-based glass.

5. The tracheal tube, as set forth in claim 1, wherein the water-soluble glass of the second formulation comprises a phosphorous-based glass.

6. The tracheal tube, as set forth in claim 1, wherein the hydrophilic polymer of the first formulation comprises polyurethane.

7. The tracheal tube. as set forth in claim 1, wherein the hydrophilic polymer of the second formulation comprises polyurethane.

8. The tracheal tube, as set forth in claim 1, wherein the hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.

9. The tracheal tube, as set forth in claim 1, wherein the inner layer comprises an indicator of carbon dioxide concentration, a bronchodilator, an anti-inflammatory agent, or a local anesthetic.

10. A method of making a medical device comprising:

forming a first hydrophobic polymer into a wall of a conduit of a medical device, forming a combination of a first hydrophilic polymer and a first water-soluble glass having a first quantity of a first metal substantially dispersed therein as an outer surface of the wall.

forming a cuff comprising a second hydrophobic polymer and a second hydrophilic polymer, wherein the second hydrophilic polymer comprises a second water-soluble glass having a second quantity of a second metal substantially dispersed therein; and

providing the cuff on the conduit.

11. The method as set forth in claim 10, wherein the first metal and second metal comprise copper, old, silver, zinc, magnesium, boron, iodine, manganese, selenium, chromium, allium or combinations thereof.

12. The method, as set Forth in claim 10, wherein forming comprises extruding, co-molding, blow molding, insert molding, injection molding, or compression molding.

13. The method, as set forth in claim 10, wherein the first water-soluble glass and second water-soluble glass comprise a phosphorous-based glass.

14. The method, as set Forth in claim 10, wherein the second hydrophobic polymer comprises an inner layer of the cuff and the second hydrophilic polymer comprises an outer layer of the cuff.

15. The method, as set forth in claim 10, wherein the second hydrophobic polymer comprises polyvinyl chloride, polyethylene, polyurethane, polydimethylsiloxane, polyester, silicone, or rubber.