BAB TRIBLOCK POLYMERS HAVING IMPROVED RELEASE CHARACTERISTICS
First Claim
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1. A BAB-block copolymer, said block copolymer comprising:
- i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and
ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons;
wherein the BAB-block copolymer has a Mw ranging from 5000 to 8000, and is capable of exhibiting reverse thermal gellation properties when formed in an aqueous polymer solution.
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Abstract
Improved biodegradable and bioabsorbable BAB-block copolymers exhibiting reverse thermal gellation properties, and aqueous polymer compositions including the BAB-block copolymers, are provided. Methods of making the improved BAB-block copolymers and compositions including the same are also provided.
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Citations
57 Claims
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1. A BAB-block copolymer, said block copolymer comprising:
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i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons; wherein the BAB-block copolymer has a Mw ranging from 5000 to 8000, and is capable of exhibiting reverse thermal gellation properties when formed in an aqueous polymer solution. - View Dependent Claims (2, 3, 4, 5, 16, 17)
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- 6. A block copolymer composition comprising the block copolymer of claim and a drug.
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18. A BAB-block copolymer, said block copolymer comprising:
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i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons; wherein the BAB-block copolymer has a Mn greater than 3800, and is capable of exhibiting reverse thermal gellation properties when formed in an aqueous polymer solution.
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19. (canceled)
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20. An aqueous BAB-block copolymer composition, said composition comprising:
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i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons; wherein the BAB-block copolymer composition has a Mw ranging from 5000 to 8000, and exhibits reverse thermal gellation properties.
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21-36. -36. (canceled)
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37. An aqueous BAB-block copolymer composition, said composition comprising:
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i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons; wherein the BAB-block copolymer composition has a Mn greater than 3800, and exhibits reverse thermal gellation properties.
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38. (canceled)
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39. A method for the administration of at least one drug to a warm blooded animal in a controlled release form which comprises:
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(1) providing an aqueous BAB-block copolymer composition comprising; i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons; wherein the BAB-block copolymer composition has a Mw ranging from 5000 to 8000, and exhibits reverse thermal gellation properties; and (2) administering said composition to a warm blooded animal.
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40-55. -55. (canceled)
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56. A method of making a BAB-block copolymer composition which comprises:
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(1) providing a BAB-block copolymer composition comprising; i) about 60 to 85% by weight of a biodegradable, hydrophobic A-block comprising a biodegradable polyester; and ii) about 15 to 40% by weight of a biodegradable, hydrophilic B-block comprising a polyethylene glycol, wherein the weight average molecular weight of each B-block is between 300 and 1000 Daltons; wherein the BAB-block copolymer composition has a Mw ranging from 5000 to 8000, and is capable of exhibiting reverse thermal gellation properties when formed in an aqueous polymer solution; and (2) freeze drying said block copolymer, wherein the wherein the block copolymer is capable of exhibiting reference thermal gellation when formed as an aqueous polymer solution.
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57-72. -72. (canceled)
Specification