METHOD OF SLOWING THE AGING PROCESS BY ACTIVATING SIRTUIN ENZYMES

• US 20110070258A1
• Filed: 09/17/2010
• Published: 03/24/2011
• Est. Priority Date: 09/18/2009
• Status: Abandoned Application

• Current Assignee: Polifenoles Naturales, S.L.
• Original Assignee: Polifenoles Naturales, S.L.
• Inventors: Flowerman, Paul, JIMENEZ DEL RIO, Miguel, Badmaev, Vladimir
• Application Number:
  US12/885,271
• Publication Number:
  US 20110070258A1
• Time in Patent Office: Days
• US Class Current: 424/195.17
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/336 having three-membered rings, e.g. oxirane, fumagillin
• CPC Class Codes: A61K 36/03 Phaeophycota or phaeophyta (brown algae), e.g. Fucus
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The fucoxanthin/pomegranate seed oil composition describes a method of slowing the aging process in a mammalian subject by activating at least one member of the sirtuin family of proteins, wherein the activating step includes administering to the subject a synergistic combination of fucoxanthin and punicic acid. Sirtuin enzymes exert their function by removing acetyl groups from proteins. The deacetylation results in inactivation of the proteins'"'"' role in cell metabolism and prevents genes from over-expression, thereby putting a cell into a state of hibernation and increasing its lifespan.

Claims

1. A method of slowing the aging process in a mammalian subject, comprising:

activating at least one member of the sirtuin family of proteins, wherein said activating comprises;

administering to said subject an effective amount of a synergistic combination of fucoxanthin and punicic acid.

2. The method recited in claim 1, wherein said administering comprises:

administering an effective amount of a synergistic combination of fucoxanthin and punicic acid, wherein said fucoxanthin is administered as a component of an extract of a brown marine vegetable.

3. The method recited in claim 1, wherein said administering comprises:

administering an effective amount of a synergistic combination of fucoxanthin and punicic acid, wherein said punicic acid is administered as a component of a pomegranate seed oil.

4. The method recited in claim 1, wherein said activating comprises activating at least one protein selected from the group consisting of Sirt1 and Sirt3 proteins;

wherein said activating places cells into a state of hibernation by deacetylating proteins.

5. The method recited in claim 1, wherein said activating comprises activating at least one mitochondrial protein selected from the group consisting of Sirt3, Sirt4, and Sirt5.

6. The method recited in claim 1, wherein said activating further comprises activating a mitochondrial UCP-1 protein.

7. The method recited in claim 1, wherein said method further comprises treatment of non-alcoholic fatty liver disease with said synergistic combination.

8. The method recited in claim 1, wherein said method further comprises treatment of fatty liver condition with said synergistic combination.

9. The method recited in claim 1, wherein said method further comprises increasing energy expenditure rate with said synergistic combination.

10. The method recited in claim 1, wherein said method further comprises:

increasing the volume of brown adipose tissue and decreasing the volume of white adipose tissue through treatment with said synergistic combination.

12. The method recited in claim 1, wherein the synergistic combination further comprises at least one omega-3 fatty acid.

13. The method recited in claim 1, wherein the synergistic combination further comprises at least one omega-3 fatty acid derived from brown algae.

14. The method recited in claim 1, wherein the synergistic combination comprises fucoxanthin derived from brown algae and at least one omega-3 fatty acid derived from brown algae.

15. The method recited in claim 1, wherein the synergistic combination comprises synthetically produced fucoxanthin and at least one omega-3 fatty acid derived from brown algae.

16. The method recited in claim 1, wherein the synergistic combination comprises:

fucoxanthin, alone or in combination with extracts of marine brown algae; and

punicic acid, alone or in combination with pomegranate seed oil.

17. The method recited in claim 1, wherein the synergistic combination comprises:

said synergistic combination of fucoxanthin and punicic acid;

wherein said fucoxanthin is included as a component of at least one extract of marine brown algae; and

wherein said punicic acid is included as a component of pomegranate seed oil.

18. A method as recited in claim 1, wherein said administering comprises topically applying or parenterally administering the synergistic combination to said subject.

19. A method as recited in claim 1, wherein said administering comprises orally administering the synergistic combination to said subject.

20. A method as recited in claim 1, wherein said subject is a human.

23. A method as recited in claim 1, wherein said extract comprises 30 wt. % of marine vegetable oil, and 0.8 wt. % fucoxanthin.

11. A method of slowing the aging process in a mammalian subject, comprising:

placing cells into a state of hibernation by deacetylating proteins, wherein said deacetylating proteins is achieved by administering to said subject an effective amount of a synergistic combination of fucoxanthin and punicic acid.

21. A method of improving body composition in a mammalian subject, comprising:

activating at least one member of the sirtuin family of proteins, wherein said activating comprises;

administering to said subject an effective amount of a synergistic combination of fucoxanthin and punicic acid.

22. A method of activating Sirt1 in adipose tissue, comprising:

contacting said tissue with an effective amount of a synergistic combination of fucoxanthin and punicic acid;

wherein said synergistic composition comprises;

50 wt. % of an extract of a brown marine vegetable, said extract comprising 30 wt. % of marine vegetable oil, and 0.5 to 5 wt. % fucoxanthin; and

50 wt. % of an pomegranate seed oil, said pomegranate seed oil comprising 60-80 wt. % of punicic acid.