Viral Vectors and Their Use in Therapeutic Methods
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Abstract
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
12 Citations
51 Claims
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1-30. -30. (canceled)
- 31. A herpes simplex virus comprising an inactivating mutation in the ICP47 locus of the virus, wherein said mutation occurs between the BstEII site and the EcoNI site of the BamH1 fragment encompassing the ICP47 region, and wherein said mutation places US11 under control of the ICP47 immediate-early promoter.
- 42. A herpes simplex virus comprising a deletion, wherein said deletion comprises the region between the BstEII site and the EcoNI site of the BamH1 fragment encompassing the ICP47 region and wherein the deletion places US11 under control of the ICP47 immediate-early promoter.
Specification