Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations

• US 20110070641A1
• Filed: 09/07/2010
• Published: 03/24/2011
• Est. Priority Date: 08/27/2003
• Status: Abandoned Application

• Current Assignee: Alexandra Capela, Ann Tsukamoto, Nobuko Uchida, Stanley Tamaki, Tim Austin
• Original Assignee: Alexandra Capela, Ann Tsukamoto, Nobuko Uchida, Stanley Tamaki, Tim Austin
• Inventors: Austin, Tim, Tsukamoto, Ann, Uchida, Nobuko, Capela, Alexandra, Tamaki, Stanley
• Application Number:
  US12/807,574
• Publication Number:
  US 20110070641A1
• Time in Patent Office: Days
• US Class Current: 435/325
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 5/48 of the pancreatic hormones
• CPC Class Codes: C07K 16/2842 against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2896 against molecules with a "CD"-designation, not provided for elsewhere
• CPC Class Codes: C12N 2501/58 Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
• CPC Class Codes: C12N 2501/599 with CD designations not provided for elsewhere
• CPC Class Codes: C12N 5/0678 Stem cells; Progenitor cells; Precursor cells
• CPC Class Codes: G01N 33/566 using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
• CPC Class Codes: G01N 33/567 utilising isolate of tissue or organ as binding agent

Abstract

Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.

Claims

1-48. -48. (canceled)

49. An isolated pancreatic stem cell population, wherein the pancreatic stem cell population is enriched for CD133⁺CD49f⁺ pancreatic stem cells.

50-52. -52. (canceled)