FREE-STANDING BIODEGRADABLE PATCH
First Claim
1. A device comprising:
- a film comprising solid fibrinogen,wherein the film is free-standing and becomes adherent when exposed to moisture.
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Accused Products
Abstract
Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.
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Citations
31 Claims
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1. A device comprising:
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a film comprising solid fibrinogen, wherein the film is free-standing and becomes adherent when exposed to moisture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A system for delivering a tissue or vessel patch, the system comprising:
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a delivery device having an expandable member; and a film comprising unreacted fibrinogen, the film configured to form an adherent patch upon exposure to moisture, wherein the film is disposed upon and delivered by the expandable member. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of delivering a patch to bodily tissue, comprising:
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advancing a free-standing film comprising unreacted fibrinogen to a target location; activating the film by exposing it to moisture; and applying the film to a bodily tissue, whereon the film forms an adherent patch. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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Specification